A systematic review and meta-analysis of imaging genetics studies of specific reading disorder

Tina Thomas, Shiva Khalaf, Elena L. Grigorenko

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

1 Цитирования (Scopus)

Аннотация

The imaging genetics of specific reading disabilities (SRD) is an emerging field that aims to characterize the disabilities’ neurobiological causes, including atypical brain structure and function and distinct genetic architecture. The present review aimed to summarize current imaging genetics studies of SRD, characterize the effect sizes of reported results by calculating Cohen’s d, complete a Fisher’s Combined Probability Test for genes featured in multiple studies, and determine areas for future research. Results demonstrate associations between SRD risk genes and reading network brain phenotypes. The Fisher’s test revealed promising results for the genes DCDC2, KIAA0319, FOXP2, SLC2A3, and ROBO1. Future research should focus on exploratory approaches to identify previously undiscovered genes. Using comprehensive neuroimaging (e.g., functional and effective connectivity) and genetic (e.g., sequencing and epigenetic) techniques, and using larger samples, diverse stages of development, and longitudinal investigations, would help researchers understand the neurobiological correlates of SRD to improve early identification.

Язык оригиналаанглийский
Страницы (с-по)179-204
Число страниц26
ЖурналCognitive Neuropsychology
Том38
Номер выпуска3
DOI
СостояниеОпубликовано - 2021

Предметные области Scopus

  • Нейропсихология и психофизиология
  • Экспериментальная и когнитивная психология
  • Психология обучения и развития
  • Гуманитарные науки и искусство (разное)
  • Когнитивная нейробиология

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