A pericyte origin of spinal cord scar tissue

Christian Göritz, David O. Dias, Nikolay Tomilin, Mariano Barbacid, Oleg Shupliakov, Jonas Frisén

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

482 Цитирования (Scopus)

Аннотация

There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.

Язык оригиналаанглийский
Страницы (с-по)238-242
Число страниц5
ЖурналScience
Том333
Номер выпуска6039
DOI
СостояниеОпубликовано - 8 июл 2011

Предметные области Scopus

  • Общие

Fingerprint

Подробные сведения о темах исследования «A pericyte origin of spinal cord scar tissue». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать