A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

T.V. Serebryanskaya, A.A. Zolotarev, I. Ott

Результат исследований: Научные публикации в периодических изданияхстатья

22 Цитирования (Scopus)

Аннотация

A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.
Язык оригиналаанглийский
Страницы (с-по)1186-1189
ЖурналMedChemComm
Том6
Номер выпуска6
DOI
СостояниеОпубликовано - 2015

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