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A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia. / Toussova, Olga V; Kozlov, Andrei P; Verevochkin, Sergei V; Lancaster, Kathryn E; Shaboltas, Alla V; Masharsky, Alexei; Dukhovlinova, Elena; Miller, William C; Hoffman, Irving F.

в: AIDS Research and Human Retroviruses, Том 34, № 3, 03.2018, стр. 261-268.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Toussova, OV, Kozlov, AP, Verevochkin, SV, Lancaster, KE, Shaboltas, AV, Masharsky, A, Dukhovlinova, E, Miller, WC & Hoffman, IF 2018, 'A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia', AIDS Research and Human Retroviruses, Том. 34, № 3, стр. 261-268. https://doi.org/10.1089/AID.2017.0076, https://doi.org/10.1089/AID.2017.0076

APA

Toussova, O. V., Kozlov, A. P., Verevochkin, S. V., Lancaster, K. E., Shaboltas, A. V., Masharsky, A., Dukhovlinova, E., Miller, W. C., & Hoffman, I. F. (2018). A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia. AIDS Research and Human Retroviruses, 34(3), 261-268. https://doi.org/10.1089/AID.2017.0076, https://doi.org/10.1089/AID.2017.0076

Vancouver

Toussova OV, Kozlov AP, Verevochkin SV, Lancaster KE, Shaboltas AV, Masharsky A и пр. A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia. AIDS Research and Human Retroviruses. 2018 Март;34(3):261-268. https://doi.org/10.1089/AID.2017.0076, https://doi.org/10.1089/AID.2017.0076

Author

Toussova, Olga V ; Kozlov, Andrei P ; Verevochkin, Sergei V ; Lancaster, Kathryn E ; Shaboltas, Alla V ; Masharsky, Alexei ; Dukhovlinova, Elena ; Miller, William C ; Hoffman, Irving F. / A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia. в: AIDS Research and Human Retroviruses. 2018 ; Том 34, № 3. стр. 261-268.

BibTeX

@article{52b9af85faa44d94b321314139102056,
title = "A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia",
abstract = "To detect acute HIV infections (AHIs) in real time among people who inject drugs (PWID) in St. Petersburg, Russia and to test the feasibility of this approach. Prospective cohort study. One hundred seronegative or acutely HIV-infected at screening PWID were enrolled and followed until the end of the 12-month pilot period. Each participant was evaluated, tested, and counseled for HIV monthly. Two HIV tests were used: HIV antibody and HIV RNA PCR. If diagnosed with AHI, participants were followed weekly for a month; then, monthly for 3 months; and then, quarterly for the duration of the follow-up period. HIV risk behavior was assessed at each study visit. Most enrolled PWID were 30-39 years old, male, completed high school or more, not employed full-time, heroin users, and frequently shared injection paraphernalia. AHI prevalence at screening was 1.8% [95% confidence interval (CI): 0.4, 5.5]. Three participants with AHI at enrollment represented 3% (95% CI: 0.6, 8.5) of the 100 participants who consented to enroll. Among the HIV-uninfected participants (n = 97), the AHI incidence over time was 9.3 per 100 person-years. Persons with AHI were more likely to report alcohol intoxication within the prior 30 days. This was the first study to detect AHI using a cohort approach. The approach proved to be feasible: recruitment, retention, AHI detection, and virological endpoints were successfully reached. A cost analysis in a real-world setting would be required to determine if this strategy could be brought to scale. The study revealed continued high HIV incidence rate among PWID in St. Petersburg, Russia and the importance of prevention and treatment programs for this group.",
keywords = "PWID cohort, Russia, acute HIV incidence, SEROCONVERSION, VIRUS, PREVENTION, CARE, ALCOHOL-USE, TRANSMISSION, PLASMA, VANCOUVER, USERS, EPIDEMIOLOGY",
author = "Toussova, {Olga V} and Kozlov, {Andrei P} and Verevochkin, {Sergei V} and Lancaster, {Kathryn E} and Shaboltas, {Alla V} and Alexei Masharsky and Elena Dukhovlinova and Miller, {William C} and Hoffman, {Irving F}",
year = "2018",
month = mar,
doi = "10.1089/AID.2017.0076",
language = "English",
volume = "34",
pages = "261--268",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - A Cohort Approach to Real-Time Detection of Acute HIV Infections Among People Who Inject Drugs in St. Petersburg, Russia

AU - Toussova, Olga V

AU - Kozlov, Andrei P

AU - Verevochkin, Sergei V

AU - Lancaster, Kathryn E

AU - Shaboltas, Alla V

AU - Masharsky, Alexei

AU - Dukhovlinova, Elena

AU - Miller, William C

AU - Hoffman, Irving F

PY - 2018/3

Y1 - 2018/3

N2 - To detect acute HIV infections (AHIs) in real time among people who inject drugs (PWID) in St. Petersburg, Russia and to test the feasibility of this approach. Prospective cohort study. One hundred seronegative or acutely HIV-infected at screening PWID were enrolled and followed until the end of the 12-month pilot period. Each participant was evaluated, tested, and counseled for HIV monthly. Two HIV tests were used: HIV antibody and HIV RNA PCR. If diagnosed with AHI, participants were followed weekly for a month; then, monthly for 3 months; and then, quarterly for the duration of the follow-up period. HIV risk behavior was assessed at each study visit. Most enrolled PWID were 30-39 years old, male, completed high school or more, not employed full-time, heroin users, and frequently shared injection paraphernalia. AHI prevalence at screening was 1.8% [95% confidence interval (CI): 0.4, 5.5]. Three participants with AHI at enrollment represented 3% (95% CI: 0.6, 8.5) of the 100 participants who consented to enroll. Among the HIV-uninfected participants (n = 97), the AHI incidence over time was 9.3 per 100 person-years. Persons with AHI were more likely to report alcohol intoxication within the prior 30 days. This was the first study to detect AHI using a cohort approach. The approach proved to be feasible: recruitment, retention, AHI detection, and virological endpoints were successfully reached. A cost analysis in a real-world setting would be required to determine if this strategy could be brought to scale. The study revealed continued high HIV incidence rate among PWID in St. Petersburg, Russia and the importance of prevention and treatment programs for this group.

AB - To detect acute HIV infections (AHIs) in real time among people who inject drugs (PWID) in St. Petersburg, Russia and to test the feasibility of this approach. Prospective cohort study. One hundred seronegative or acutely HIV-infected at screening PWID were enrolled and followed until the end of the 12-month pilot period. Each participant was evaluated, tested, and counseled for HIV monthly. Two HIV tests were used: HIV antibody and HIV RNA PCR. If diagnosed with AHI, participants were followed weekly for a month; then, monthly for 3 months; and then, quarterly for the duration of the follow-up period. HIV risk behavior was assessed at each study visit. Most enrolled PWID were 30-39 years old, male, completed high school or more, not employed full-time, heroin users, and frequently shared injection paraphernalia. AHI prevalence at screening was 1.8% [95% confidence interval (CI): 0.4, 5.5]. Three participants with AHI at enrollment represented 3% (95% CI: 0.6, 8.5) of the 100 participants who consented to enroll. Among the HIV-uninfected participants (n = 97), the AHI incidence over time was 9.3 per 100 person-years. Persons with AHI were more likely to report alcohol intoxication within the prior 30 days. This was the first study to detect AHI using a cohort approach. The approach proved to be feasible: recruitment, retention, AHI detection, and virological endpoints were successfully reached. A cost analysis in a real-world setting would be required to determine if this strategy could be brought to scale. The study revealed continued high HIV incidence rate among PWID in St. Petersburg, Russia and the importance of prevention and treatment programs for this group.

KW - PWID cohort

KW - Russia

KW - acute HIV incidence

KW - SEROCONVERSION

KW - VIRUS

KW - PREVENTION

KW - CARE

KW - ALCOHOL-USE

KW - TRANSMISSION

KW - PLASMA

KW - VANCOUVER

KW - USERS

KW - EPIDEMIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=85045106148&partnerID=8YFLogxK

U2 - 10.1089/AID.2017.0076

DO - 10.1089/AID.2017.0076

M3 - Article

C2 - 29145741

VL - 34

SP - 261

EP - 268

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 3

ER -

ID: 13394656