2 H-Azirines as C-C Annulation Reagents in Cu-Catalyzed Synthesis of Furo[3,2-c]quinolone Derivatives

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)


A method of furo-annulation of 4-hydroxy-2-oxoquinoline-3-carboxylates with 3-arylazirines under Cu(II) catalysis was developed to synthesize a variety of 2,3-dihydrofuro[3,2-c]quinolones bearing a carbamate group at the C2 position. The reaction involves an azirine ring opening across the N-C2 bond and formation of a dihydrofuran ring with the inclusion of two azirine carbon atoms, accompanied by a shift of the ester group to the nitrogen. The discovered reaction is the first example of the use of 2H-azirines for furo-annulation.

Язык оригиналаанглийский
Страницы (с-по)3615-3619
Число страниц5
ЖурналOrganic Letters
Номер выпуска10
СостояниеОпубликовано - 17 мая 2019


Предметные области Scopus

  • Биохимия
  • Физическая и теоретическая химия
  • Органическая химия