18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

V.M. Petriev, V.K. Tishchenko, R. N. Krasikova

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

3 Цитирования (Scopus)

Выдержка

This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90% of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.

Язык оригиналаАнглийский
Страницы (с-по)209-220
Число страниц12
ЖурналPharmaceutical Chemistry Journal
Том50
Номер выпуска4
DOI
СостояниеОпубликовано - авг 2016

Цитировать

Petriev, V.M. ; Tishchenko, V.K. ; Krasikova, R. N. / 18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review). В: Pharmaceutical Chemistry Journal. 2016 ; Том 50, № 4. стр. 209-220.
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abstract = "This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90{\%} of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.",
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author = "V.M. Petriev and V.K. Tishchenko and Krasikova, {R. N.}",
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18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review). / Petriev, V.M.; Tishchenko, V.K.; Krasikova, R. N.

В: Pharmaceutical Chemistry Journal, Том 50, № 4, 08.2016, стр. 209-220.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

TY - JOUR

T1 - 18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

AU - Petriev, V.M.

AU - Tishchenko, V.K.

AU - Krasikova, R. N.

PY - 2016/8

Y1 - 2016/8

N2 - This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90% of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.

AB - This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90% of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.

KW - 2-[F-18]Fluoro-2-deoxy-D-glucose

KW - F-18-FDG

KW - radiopharmaceutical preparations

KW - radiotracers

KW - oncological diagnosis

KW - positron emission tomography

KW - PET

KW - single-photon emission computed tomography

KW - SPECT

KW - planar scintigraphy

KW - PS

KW - labeled glucose derivatives

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - STANDARDIZED UPTAKE VALUE

KW - DIFFERENTIATED THYROID-CARCINOMA

KW - RECURRENT COLORECTAL-CANCER

KW - GERM-CELL TUMORS

KW - FDG-PET

KW - BIOLOGICAL EVALUATION

KW - DEOXYGLUCOSE DERIVATIVES

KW - FLUORODEOXYGLUCOSE PET

KW - BREAST-CANCER

U2 - 10.1007/s11094-016-1425-y

DO - 10.1007/s11094-016-1425-y

M3 - Обзорная статья

VL - 50

SP - 209

EP - 220

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 4

ER -