Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Генотоксический эффект действия иммобилизации и феромонального стрессора в соматических и половых клетках самцов мышей Mus musculus L. / Shcherbinina, Veronika D.; Petrova, Marina V.; Glinin, Timofey S.; Daev, Eugene V.
в: Ecological Genetics, Том 19, № 2, 27.07.2021, стр. 169-179.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Генотоксический эффект действия иммобилизации и феромонального стрессора в соматических и половых клетках самцов мышей Mus musculus L.
AU - Shcherbinina, Veronika D.
AU - Petrova, Marina V.
AU - Glinin, Timofey S.
AU - Daev, Eugene V.
N1 - Publisher Copyright: © Eco-Vector, 2021
PY - 2021/7/27
Y1 - 2021/7/27
N2 - BACKGROUND: Different stressors affect the genome integrity, but the mechanisms of such action are underexplored. MATERIALS AND METHODS: Bone marrow and testicular cells of CBA and CD-1 mouse males were used to estimate their genome integrity after stressor action by the comet assay. RESULTS: It is shown here that restraint and 2,5-dimethylpyrazine both increase damaged cell frequency in bone marrow as well as in testes of mouse males. For the first time the effect of immobilization and 2,5-dimethylpyrazine in testicular cells is demonstrated using the comet assay. Both stressors have similar effects in cells of both tissues analyzed. CONCLUSION: Mechanisms of the effects and possible role in microevolution are under discussion.
AB - BACKGROUND: Different stressors affect the genome integrity, but the mechanisms of such action are underexplored. MATERIALS AND METHODS: Bone marrow and testicular cells of CBA and CD-1 mouse males were used to estimate their genome integrity after stressor action by the comet assay. RESULTS: It is shown here that restraint and 2,5-dimethylpyrazine both increase damaged cell frequency in bone marrow as well as in testes of mouse males. For the first time the effect of immobilization and 2,5-dimethylpyrazine in testicular cells is demonstrated using the comet assay. Both stressors have similar effects in cells of both tissues analyzed. CONCLUSION: Mechanisms of the effects and possible role in microevolution are under discussion.
KW - 2,5-dimethylpyrazine
KW - Bone marrow
KW - Comet assay
KW - Genome
KW - Mouse
KW - Pheromone
KW - Restraint
KW - Stress
KW - Testes
KW - 2,5-dimethylpyrazine
KW - Bone marrow
KW - Comet assay
KW - Genome
KW - Mouse
KW - Pheromone
KW - Restraint
KW - Stress
KW - Testes
UR - http://www.scopus.com/inward/record.url?scp=85113189946&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ac3379e1-84d7-330a-ab23-4ebb62932d87/
U2 - 10.17816/ECOGEN65208
DO - 10.17816/ECOGEN65208
M3 - статья
AN - SCOPUS:85113189946
VL - 19
SP - 169
EP - 179
JO - ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА
JF - ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА
SN - 1811-0932
IS - 2
ER -
ID: 85274509