Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF

Переведенное название: Терапия Диеногестом после удаления эндометриомы у женщин с бесплодием перед ЭКО

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

1 цитирование (Scopus)

Выдержка

BACKGROUND: Severe forms of genital endometriosis are known to be associated with infertility and its subsequent treatment failure. Both gonadotropin-releasing hormone analogs (a-GnRH) and dienogest have been suggested as additional hormone therapy for patients with endometriomas. However, the result of hormonal suppression before an in vitro fertilization (IVF) cycle remains undetermined. MATERIALS AND METHODS: A prospective cohort study of 144 infertile women planning IVF after laparoscopic surgery of ovarian endometriomas was conducted at our department in 2012-2015. Patients were divided into three groups: group I (N = 38) with dienogest course, group II (N = 70) with a-GnRH group III (N = 70) without any hormonal therapy within 6 months preceding IVF. RESULTS: The study groups did not differ by removed endometriomas size and ovarian reserve indicators. The gonadotropin dose per Cycle was higher, while the number of retrieved oocytes was lower in group III patients (p < .001). In women with dienogest pretreatment, clinical pregnancy rate was 2.5 times (44.7% versus 16.7%, p = .012) and delivery rate - three times higher (36.8% versus 11.1%, p = .013) as compared with those from group III. CONCLUSIONS: The present study confirms the necessity of pre-cycle medical interventions in women with ovarian forms of endometriosis undergoing IVF. We suggest dienogest to be possibly more efficient treatment option for this kind of patients
Язык оригиналаанглийский
Номер статьиdoi: 10.1080/09513590.2017.1415676
Страницы (с-по)18-21
Число страниц4
ЖурналGynecological Endocrinology
Том33
Номер выпускаsup 1
СостояниеОпубликовано - 2017

Ключевые слова

  • Dienogest; GnRH agonist; IVF; assisted reproduction; endometrioma; endometriosis; in vitro fertilization

Предметные области Scopus

  • Медицина (все)

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title = "Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF",
abstract = "BACKGROUND: Severe forms of genital endometriosis are known to be associated with infertility and its subsequent treatment failure. Both gonadotropin-releasing hormone analogs (a-GnRH) and dienogest have been suggested as additional hormone therapy for patients with endometriomas. However, the result of hormonal suppression before an in vitro fertilization (IVF) cycle remains undetermined. MATERIALS AND METHODS: A prospective cohort study of 144 infertile women planning IVF after laparoscopic surgery of ovarian endometriomas was conducted at our department in 2012-2015. Patients were divided into three groups: group I (N = 38) with dienogest course, group II (N = 70) with a-GnRH group III (N = 70) without any hormonal therapy within 6 months preceding IVF. RESULTS: The study groups did not differ by removed endometriomas size and ovarian reserve indicators. The gonadotropin dose per Cycle was higher, while the number of retrieved oocytes was lower in group III patients (p < .001). In women with dienogest pretreatment, clinical pregnancy rate was 2.5 times (44.7{\%} versus 16.7{\%}, p = .012) and delivery rate - three times higher (36.8{\%} versus 11.1{\%}, p = .013) as compared with those from group III. CONCLUSIONS: The present study confirms the necessity of pre-cycle medical interventions in women with ovarian forms of endometriosis undergoing IVF. We suggest dienogest to be possibly more efficient treatment option for this kind of patients",
keywords = "Dienogest; GnRH agonist; IVF; assisted reproduction; endometrioma; endometriosis; in vitro fertilization",
author = "Ниаури, {Дарико Александровна} and Гзгзян, {Александр Мкртичевич} and Айламазян, {Эдуард Карпович}",
note = "Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF. Muller V, Kogan I, Yarmolinskaya M, Niauri D, Gzgzyan A, Aylamazyan E // Gynecol Endocrinol. 2017;33(sup1):18-21",
year = "2017",
language = "English",
volume = "33",
pages = "18--21",
journal = "Gynecological Endocrinology",
issn = "0951-3590",
publisher = "Taylor & Francis",
number = "sup 1",

}

Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF. / Ниаури, Дарико Александровна; Гзгзян, Александр Мкртичевич; Айламазян, Эдуард Карпович.

В: Gynecological Endocrinology, Том 33, № sup 1, doi: 10.1080/09513590.2017.1415676, 2017, стр. 18-21.

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

TY - JOUR

T1 - Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF

AU - Ниаури, Дарико Александровна

AU - Гзгзян, Александр Мкртичевич

AU - Айламазян, Эдуард Карпович

N1 - Dienogest treatment after ovarian endometrioma removal in infertile women prior to IVF. Muller V, Kogan I, Yarmolinskaya M, Niauri D, Gzgzyan A, Aylamazyan E // Gynecol Endocrinol. 2017;33(sup1):18-21

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Severe forms of genital endometriosis are known to be associated with infertility and its subsequent treatment failure. Both gonadotropin-releasing hormone analogs (a-GnRH) and dienogest have been suggested as additional hormone therapy for patients with endometriomas. However, the result of hormonal suppression before an in vitro fertilization (IVF) cycle remains undetermined. MATERIALS AND METHODS: A prospective cohort study of 144 infertile women planning IVF after laparoscopic surgery of ovarian endometriomas was conducted at our department in 2012-2015. Patients were divided into three groups: group I (N = 38) with dienogest course, group II (N = 70) with a-GnRH group III (N = 70) without any hormonal therapy within 6 months preceding IVF. RESULTS: The study groups did not differ by removed endometriomas size and ovarian reserve indicators. The gonadotropin dose per Cycle was higher, while the number of retrieved oocytes was lower in group III patients (p < .001). In women with dienogest pretreatment, clinical pregnancy rate was 2.5 times (44.7% versus 16.7%, p = .012) and delivery rate - three times higher (36.8% versus 11.1%, p = .013) as compared with those from group III. CONCLUSIONS: The present study confirms the necessity of pre-cycle medical interventions in women with ovarian forms of endometriosis undergoing IVF. We suggest dienogest to be possibly more efficient treatment option for this kind of patients

AB - BACKGROUND: Severe forms of genital endometriosis are known to be associated with infertility and its subsequent treatment failure. Both gonadotropin-releasing hormone analogs (a-GnRH) and dienogest have been suggested as additional hormone therapy for patients with endometriomas. However, the result of hormonal suppression before an in vitro fertilization (IVF) cycle remains undetermined. MATERIALS AND METHODS: A prospective cohort study of 144 infertile women planning IVF after laparoscopic surgery of ovarian endometriomas was conducted at our department in 2012-2015. Patients were divided into three groups: group I (N = 38) with dienogest course, group II (N = 70) with a-GnRH group III (N = 70) without any hormonal therapy within 6 months preceding IVF. RESULTS: The study groups did not differ by removed endometriomas size and ovarian reserve indicators. The gonadotropin dose per Cycle was higher, while the number of retrieved oocytes was lower in group III patients (p < .001). In women with dienogest pretreatment, clinical pregnancy rate was 2.5 times (44.7% versus 16.7%, p = .012) and delivery rate - three times higher (36.8% versus 11.1%, p = .013) as compared with those from group III. CONCLUSIONS: The present study confirms the necessity of pre-cycle medical interventions in women with ovarian forms of endometriosis undergoing IVF. We suggest dienogest to be possibly more efficient treatment option for this kind of patients

KW - Dienogest; GnRH agonist; IVF; assisted reproduction; endometrioma; endometriosis; in vitro fertilization

M3 - Article

VL - 33

SP - 18

EP - 21

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

IS - sup 1

M1 - doi: 10.1080/09513590.2017.1415676

ER -