СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ

C. T. Nguyen, D. A. Niauri, L. Kh Dzhemlikhanova, I. Yu Kogan, I. O. Krikheli, I. D. Mekina, E. A. Lesik, E. M. Komarova, M. A. Ishchuk, A. M. Gzgzyan

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-Müllerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.

Переведенное названиеSUBOPTIMAL RESPONSE to CONTROLLED OVARIAN STIMULATION in IVF / ICSI CYCLES
Язык оригиналарусский
Страницы (с-по)61-70
Число страниц10
ЖурналЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ
Том69
Номер выпуска6
DOI
СостояниеОпубликовано - 2020

Предметные области Scopus

  • Акушерство и гинекология

Ключевые слова

  • Clinical pregnancy rate
  • Controlled ovarian stimulation
  • IVF / icsi
  • Suboptimal response

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