Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa

Переведенное название: Ступенчатая эволюция Salmonella Typhimurium ST313, вызывающих инфекции крови в Африке

Caisey V. Pulford, Blanca M. Perez-Sepulveda, Rocío Canals, Jessica A. Bevington, Rebecca J. Bengtsson, Nicolas Wenner, Ella V. Rodwell, Benjamin Kumwenda, Xiaojun Zhu, Rebecca J. Bennett, George E. Stenhouse, P. Malaka De Silva, Hermione J. Webster, Jose A. Bengoechea, Amy Dumigan, Alicia Tran-Dien, Reenesh Prakash, Happy C. Banda, Lovemore Alufandika, Mike P. MautangaArthur Bowers-Barnard, Alexandra Y. Beliavskaia, Alexander V. Predeus, Will P.M. Rowe, Alistair C. Darby, Neil Hall, François Xavier Weill, Melita A. Gordon, Nicholas A. Feasey, Kate S. Baker, Jay C.D. Hinton

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

19 Цитирования (Scopus)


Bloodstream infections caused by nontyphoidal Salmonella are a major public health concern in Africa, causing ~49,600 deaths every year. The most common Salmonella enterica pathovariant associated with invasive nontyphoidal Salmonella disease is Salmonella Typhimurium sequence type (ST)313. It has been proposed that antimicrobial resistance and genome degradation has contributed to the success of ST313 lineages in Africa, but the evolutionary trajectory of such changes was unclear. Here, to define the evolutionary dynamics of ST313, we sub-sampled from two comprehensive collections of Salmonella isolates from African patients with bloodstream infections, spanning 1966 to 2018. The resulting 680 genome sequences led to the discovery of a pan-susceptible ST313 lineage (ST313 L3), which emerged in Malawi in 2016 and is closely related to ST313 variants that cause gastrointestinal disease in the United Kingdom and Brazil. Genomic analysis revealed degradation events in important virulence genes in ST313 L3, which had not occurred in other ST313 lineages. Despite arising only recently in the clinic, ST313 L3 is a phylogenetic intermediate between ST313 L1 and L2, with a characteristic accessory genome. Our in-depth genotypic and phenotypic characterization identifies the crucial loss-of-function genetic events that occurred during the stepwise evolution of invasive S. Typhimurium across Africa.

Переведенное названиеСтупенчатая эволюция Salmonella Typhimurium ST313, вызывающих инфекции крови в Африке
Язык оригиналаанглийский
Страницы (с-по)327-338
Число страниц12
ЖурналNature Microbiology
Номер выпуска3
СостояниеОпубликовано - мар 2021

Предметные области Scopus

  • Прикладная микробиология и биотехника
  • Микробиология (медицинская)
  • Генетика
  • Клеточная биология
  • Микробиология
  • Иммунология


Подробные сведения о темах исследования «Ступенчатая эволюция Salmonella Typhimurium ST313, вызывающих инфекции крови в Африке». Вместе они формируют уникальный семантический отпечаток (fingerprint).