Nanogels Capable of Triggered Release

Переведенное название: Наногели, способные к взрывному высвобождению лекарств

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийглава/разделнаучнаярецензирование

Аннотация

This chapter provides an overview of soft and environmentally sensitive
polymeric nanosystems, which are widely known as nanogels. These particles keep great promise to the area of drug delivery due to their high biocompatibility with body fluids and tissues, as well as due to their ability to encapsulate and release the loaded drugs in a controlled manner. For a long period of time, the controlled drug delivery systems were designed to provide long-termed or sustained release. However, some medical treatments such as cancer chemotherapy, protein and gene delivery do not require the prolonged release of the drug in the site of action. In contrast, the rapid increase of the drug concentration is needed for gaining the desired biological effect. Being very sensitive to surrounding media and different stimuli, nanogels can undergo physico-chemical transitions or chemical changes in their structure. Such changes can result in more rapid release of the drugs, which is usually referred to as triggered drug release. Herein we give the basic information on nanogel unique features, methods of sensitive nanogels preparation, as well as on
main mechanisms of triggered release. Additionally, the triggered release of
low-molecular drugs and biomacromolecules are discussed.
Переведенное названиеНаногели, способные к взрывному высвобождению лекарств
Язык оригиналаанглийский
Название основной публикацииTunable Hydrogels: Smart Materials for Biomedical Applications
Место публикацииBerlin, Heidelberg
ИздательSpringer Nature
Страницы1-48
Число страниц48
DOI
СостояниеОпубликовано - 5 мар 2021

Серия публикаций

НазваниеAdvances in Biochemical Engineering/Biotechnology
ИздательSpringer
ISSN (печатное издание)0724-6145

Ключевые слова

  • системы доставки генетических лекарств
  • наногели
  • высвобождение лекарств
  • резкое высвобождение

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