Caffeine-DNA interaction and modification of radiation damage

Переведенное название: Взаимодействие кофеина с ДНК и модификация радиационного повреждения

Результат исследований: Материалы конференцийтезисынаучная

Выдержка

We studied DNA interaction with caffeine and ions Mg2+ and Cu2+ in water solutions and dried films and influence of caffeine on DNA radiation damage. The main research methods were UV and IR-spectroscopy, UVCD, low gradient viscometry and atomic force microscopy. The results shows the caffeine-ions complexation, stronger with Cu2+ than with Mg2+. Addition of the third component to the DNA solution leads to the arising the DNA-caffeine-Me2+ complexes embracing the nitrogenous bases, which can be responsible for the prooxidant action. At the absence of divalent cations caffeine reveals the radioprotective action on DNA in solutions. In the presence of caffeine a decrease in the radiation effect on the DNA coil size in the solution, in the number of double-stranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.
Язык оригиналаанглийский
Страницы081
Число страниц1
СостояниеОпубликовано - 13 ноя 2018

Ключевые слова

  • caffeine
  • ionizing radiation
  • DNA solutions and films
  • metal ions

Цитировать

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title = "Caffeine-DNA interaction and modification of radiation damage",
abstract = "We studied DNA interaction with caffeine and ions Mg2+ and Cu2+ in water solutions and dried films and influence of caffeine on DNA radiation damage. The main research methods were UV and IR-spectroscopy, UVCD, low gradient viscometry and atomic force microscopy. The results shows the caffeine-ions complexation, stronger with Cu2+ than with Mg2+. Addition of the third component to the DNA solution leads to the arising the DNA-caffeine-Me2+ complexes embracing the nitrogenous bases, which can be responsible for the prooxidant action. At the absence of divalent cations caffeine reveals the radioprotective action on DNA in solutions. In the presence of caffeine a decrease in the radiation effect on the DNA coil size in the solution, in the number of double-stranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.",
keywords = "caffeine, ionizing radiation, DNA solutions and films, metal ions",
author = "Пастон, {Софья Владимировна}",
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Caffeine-DNA interaction and modification of radiation damage. / Пастон, Софья Владимировна.

2018. 081.

Результат исследований: Материалы конференцийтезисынаучная

TY - CONF

T1 - Caffeine-DNA interaction and modification of radiation damage

AU - Пастон, Софья Владимировна

PY - 2018/11/13

Y1 - 2018/11/13

N2 - We studied DNA interaction with caffeine and ions Mg2+ and Cu2+ in water solutions and dried films and influence of caffeine on DNA radiation damage. The main research methods were UV and IR-spectroscopy, UVCD, low gradient viscometry and atomic force microscopy. The results shows the caffeine-ions complexation, stronger with Cu2+ than with Mg2+. Addition of the third component to the DNA solution leads to the arising the DNA-caffeine-Me2+ complexes embracing the nitrogenous bases, which can be responsible for the prooxidant action. At the absence of divalent cations caffeine reveals the radioprotective action on DNA in solutions. In the presence of caffeine a decrease in the radiation effect on the DNA coil size in the solution, in the number of double-stranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.

AB - We studied DNA interaction with caffeine and ions Mg2+ and Cu2+ in water solutions and dried films and influence of caffeine on DNA radiation damage. The main research methods were UV and IR-spectroscopy, UVCD, low gradient viscometry and atomic force microscopy. The results shows the caffeine-ions complexation, stronger with Cu2+ than with Mg2+. Addition of the third component to the DNA solution leads to the arising the DNA-caffeine-Me2+ complexes embracing the nitrogenous bases, which can be responsible for the prooxidant action. At the absence of divalent cations caffeine reveals the radioprotective action on DNA in solutions. In the presence of caffeine a decrease in the radiation effect on the DNA coil size in the solution, in the number of double-stranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.

KW - caffeine

KW - ionizing radiation

KW - DNA solutions and films

KW - metal ions

M3 - Abstract

SP - 081

ER -