TY - JOUR
T1 - Anti-Idiotypic Agonistic Antibodies
T2 - Candidates for the Role of Universal Remedy
AU - Stanova, Aliya K.
AU - Ryabkova, Varvara A.
AU - Tillib, Sergei V.
AU - Utekhin, Vladimir J.
AU - Churilov, Leonid P
AU - Shoenfeld, Yehuda
PY - 2020/6
Y1 - 2020/6
N2 - Anti-idiotypic antibodies (anti-IDs) were discovered at the very beginning of the 20th century and have attracted attention of researchers for many years. Nowadays, there are five known types of anti-IDs: alpha, beta, gamma, epsilon, and delta. Due to the ability of internal-image anti-IDs to compete with an antigen for binding to antibody and to alter the biologic activity of an antigen, anti-IDs have become a target in the search for new treatments of autoimmune illnesses, cancer, and some other diseases. In this review, we summarize the data about anti-IDs that mimic the structural and functional properties of some bioregulators (autacoids, neurotransmitters, hormones, xenobiotics, and drugs) and evaluate their possible medical applications. The immune system is potentially able to reproduce or at least alter the effects of any biologically active endogenous or exogenous immunogenic agent via the anti-idiotypic principle, and probably regulates a broad spectrum of cell functions in the body, being a kind of universal remedy or immunacea, by analogy to the legendary ancient goddess of universal healing Panacea (pi alpha nu alpha kappa epsilon iota alpha, Panakeia in Greek) in the treatment and prevention of diseases, possibly including non-infectious somatic and even hereditary ones.
AB - Anti-idiotypic antibodies (anti-IDs) were discovered at the very beginning of the 20th century and have attracted attention of researchers for many years. Nowadays, there are five known types of anti-IDs: alpha, beta, gamma, epsilon, and delta. Due to the ability of internal-image anti-IDs to compete with an antigen for binding to antibody and to alter the biologic activity of an antigen, anti-IDs have become a target in the search for new treatments of autoimmune illnesses, cancer, and some other diseases. In this review, we summarize the data about anti-IDs that mimic the structural and functional properties of some bioregulators (autacoids, neurotransmitters, hormones, xenobiotics, and drugs) and evaluate their possible medical applications. The immune system is potentially able to reproduce or at least alter the effects of any biologically active endogenous or exogenous immunogenic agent via the anti-idiotypic principle, and probably regulates a broad spectrum of cell functions in the body, being a kind of universal remedy or immunacea, by analogy to the legendary ancient goddess of universal healing Panacea (pi alpha nu alpha kappa epsilon iota alpha, Panakeia in Greek) in the treatment and prevention of diseases, possibly including non-infectious somatic and even hereditary ones.
KW - anti-idiotypic antibodies
KW - agonistic autoantibodies
KW - autacoid
KW - drug
KW - hormone
KW - neurotransmitter
KW - ANTI-IDIOTYPIC ANTIBODIES
KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS
KW - PROLACTIN RECEPTOR ANTIBODIES
KW - INSULIN-RECEPTOR
KW - YERSINIA-ENTEROCOLITICA
KW - MONOCLONAL-ANTIBODIES
KW - INTERNAL IMAGES
KW - NETWORK THEORY
KW - BINDING-SITES
KW - AUTOANTIBODIES
UR - https://www.mendeley.com/catalogue/b64951d3-f971-3194-957e-e828a1281a62/
U2 - 10.3390/antib9020019
DO - 10.3390/antib9020019
M3 - Обзорная статья
C2 - 32481667
VL - 9
SP - 19
JO - Antibodies
JF - Antibodies
SN - 2073-4468
IS - 2
M1 - 19
ER -