Introduction Today, the word -pandemic" no longer seems unfamiliar or inaccessible. We are experiencing a new historical stage in the fight against COVID- 19. Epidemics, or worse, pandemics, have plagued humanity throughout its history. For millennia, medicine has struggled in its own way with both local and global diseases of humanity. Using history as an example, we can observe the importance of human immunity when faced with diseases, where vaccination is a key factor. Thanks to vaccination, millions of lives have been saved, and the morbidity and mortality of populations have been reduced. Vaccination is the most effective and cost-effective preventive measure known in modern medicine.1 Despite the obvious usefulness and effectiveness of vaccination, many people in the world feel ambiguous about getting vaccinated. Usually, vaccination means the introduction of a substance into the body that is recognized by the immune system as the causative agent of an infectious disease, as a result of which an immune response develops, which in turn leads to the production of antibodies that neutralize the pathogen when re-entering. The purpose of this study is to determine the attitude of students of American and Russian universities towards vaccination against COVID-19. The relevance of this study is due to the fact that humanity is struggling with a deadly pandemic. In order to combat coronavirus infection, a number of vaccines have been developed to reduce the level of disease and mortality in the world. Since 2020, the entire world has been forced to live in isolation and fear for their own lives and the lives of their loved ones. Now there is an opportunity to protect yourself and others by getting vaccinated against COVID-19. Despite this possibility, there are a number of concerns on the part of people that the vaccine itself was released quite early and passed the test of time.