The aim of this work was to develop high-performance membranes based on PA modified with titanium oxide and to study the effect of the photocatalyst (titanium oxide) on the membrane physicochemical properties and transport characteristics in ultrafiltration. Structure and physicochemical properties of the developed membranes were investigated by various analysis methods (SEM and AFM microscopies, the measurement of contact angle and the standard porosimetry method). Transport properties of the obtained membranes were evaluated in ultrafiltration of cutting fluid and model system of protein. It was demonstrated that the bulk modification of PA membranes with the titanium oxide particles led to a significant improvement of the membrane transport characteristics and antifouling stability due to significant changes in membrane structure.