Azapolyene strategy for the synthesis of nitrogen heterocycles

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The development of efficient methods for the synthesis of new organic com-pounds with useful properties, most of which belong
to the class of nitrogen-containing heterocycles, is one of the fundamental tasks of synthetic organic chemistry. The report
discusses one of the strategies currently being developed for the formation of monocyclic, ortho-fused and bridged heterocyclic
systems, based on carbenoid-mediated generation of azapolyene intermediates and their subsequent pericyclic, pseudopericyclic or
nucleophile-initiated cyclizations.1,2 The high synthetic potential of the proposed approach is due to the wide range and synthetic
availability of the starting compounds, as well as to the high reac-tivity of the azapolyene intermediates themselves, which under
mild conditions can form small strained rings, can involve stable benzoid aromatic systems in the cyclization process, and also can
react with weak nucleophiles as cyclization initiators.
Translated title of the contributionXXI Менделеевский съезд по теоретической и прикладной химии, Сборник тезисов-1, С.-Петербург, 9-13 сентября 2019: Азаполиеновая стратегия в синтезе азотистых гетероциклов
Original languageEnglish
Title of host publicationХХI Mendeleev Congress on General and Applied Chemistry
Subtitle of host publicationBook 1: Abstracts
StatePublished - 2019
EventХХI Mendeleev Congress on General and Applied Chemistry - Saint Petersburg, Russian Federation
Duration: 9 Sep 201913 Sep 2019


ConferenceХХI Mendeleev Congress on General and Applied Chemistry
Country/TerritoryRussian Federation
CitySaint Petersburg

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