Water-Soluble Form of 1-Alkyl(Aryl)Imidazole-4,5-Dicarboxylic Acids. Structure and Anticonvulsant Activity of the Triethanolammonium Salt of 1-Propylimidazole-4,5-Dicarboxylic Acid

M. A. Brusina, D. N. Nikolaev, V. S. Fundamenskii, V. V. Gurzhii, A. A. Zolotarev, A. V. Selitrenikov, Yu Zevatskii, A. M. Potapkin, S. M. Ramsh, L. B. Piotrovskii

Research output

1 Citation (Scopus)

Abstract

Water-soluble forms of a series of 1-alkyl(aryl)imidazole-4,5-dicarboxylic acids were prepared. Anticonvulsant activity of 1-propylimidazole-4,5-dicarboxylic acid and its triethanolammonium salt was studied using the NMDA-induced convulsion model. The triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid was shown to possess anticonvulsant activity whereas the acid itself was a convulsant. The change of pharmacological profile was related to the formation of ion pairs or associates even in polar physiological media. The ability to associate was confirmed using conductivity measurements. An x-ray crystal structure analysis was performed for the triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalPharmaceutical Chemistry Journal
Volume52
Issue number4
DOIs
Publication statusPublished - 1 Jul 2018

Scopus subject areas

  • Pharmacology
  • Drug Discovery

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