Vzaimodeistvie molekuly DNK s koordinatsionnymi soedineniiami platiny i kobal'ta v rastvore.

Translated title of the contribution: Interactions of a DNA molecule with coordination compounds of platinum and cobalt in solutions

N. A. Kas'ianenko, A. A. Bogdanov, C. Defrenne

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of DNA with coordination compounds of divalent platinum and trivalent cobalt was studied. Complexes containing simultaneously different coordination compounds were prepared by various procedures. It was shown that the binding of trans-diaminodichloroplatinum (DDP) to DNA prevents its further complexing with cis-DDP, while in the presence of cis-DDP the possibility for trans-DDP to bind to DNA in solution remains. The study of similar DNA complexes with trans-DDP and cobalt hexamine indicated the competition for the binding sites of these compounds to the DNA molecule.

Translated title of the contributionInteractions of a DNA molecule with coordination compounds of platinum and cobalt in solutions
Original languageRussian
Pages (from-to)449-452
Number of pages4
JournalBiofizika
Volume47
Issue number3
StatePublished - 2002

Scopus subject areas

  • Medicine(all)

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