Use of multidimensional evaluation for estimation of antihypoxic therapy action in the early period after lethal irradiation

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Use of multidimensional evaluation for estimation of antihypoxic therapy action in the early period after lethal irradiation. / Rozanov, V. A.; Lobasyuk, B. A.; Rejtarova, T. E.; Chernikov, G. B.; Petrov, A. P.; Kozozaeva, O. O.

In: Radiatsionnaya Biologiya. Radioekologiya, Vol. 34, No. 2, 01.03.1994, p. 292-299.

Research output: Contribution to journal › Article › peer-review

Author

Rozanov, V. A. ; Lobasyuk, B. A. ; Rejtarova, T. E. ; Chernikov, G. B. ; Petrov, A. P. ; Kozozaeva, O. O. / Use of multidimensional evaluation for estimation of antihypoxic therapy action in the early period after lethal irradiation. In: Radiatsionnaya Biologiya. Radioekologiya. 1994 ; Vol. 34, No. 2. pp. 292-299.

BibTeX

@article{304919ab883c4d12927f867bab9c75dd,

title = "Use of multidimensional evaluation for estimation of antihypoxic therapy action in the early period after lethal irradiation",

abstract = "Three groups of rats (intact, irradiated with 30 Gy of γ-rays and threated after irradiation with the use of pharmacological and metabolic drugs protecting brain against hypoxia were studied. In 24 hours after the influence the animals have undergone the neurobehavioral testing and then were sacrificed, a number of neurochemical parameters depicting energy metabolism and metabolic GABA-bypath in brain were studied (general number of parameters were 24). Using classical method of t-statistics only enhancement of labelled GBA catabolism and deterioration of general behavioral activity were verified, the modifying effect of the pharmacological and metabolic protection against hypoxia was not found. Using methods of multidimensional evaluation the protective and sanogenic character of the used method of therapy was verified. Thus, using discrimination analysis (Mahalanobis criterion) high similarity of intact and treated groups of animals was estimated. It was confirmed using methods of coupled and multiple correlation and method of route coefficients. The statistical connections between neurochemical and neurobehavioral parameters were found which can be useful for understanding of the mechanisms of the early postradiation syndrome development.",

author = "Rozanov, {V. A.} and Lobasyuk, {B. A.} and Rejtarova, {T. E.} and Chernikov, {G. B.} and Petrov, {A. P.} and Kozozaeva, {O. O.}",

year = "1994",

month = mar,

day = "1",

language = "русский",

volume = "34",

pages = "292--299",

journal = "РАДИАЦИОННАЯ БИОЛОГИЯ. РАДИОЭКОЛОГИЯ",

issn = "0869-8031",

publisher = "Издательство {"}Наука{"}",

number = "2",

}

RIS

TY - JOUR

T1 - Use of multidimensional evaluation for estimation of antihypoxic therapy action in the early period after lethal irradiation

AU - Rozanov, V. A.

AU - Lobasyuk, B. A.

AU - Rejtarova, T. E.

AU - Chernikov, G. B.

AU - Petrov, A. P.

AU - Kozozaeva, O. O.

PY - 1994/3/1

Y1 - 1994/3/1

N2 - Three groups of rats (intact, irradiated with 30 Gy of γ-rays and threated after irradiation with the use of pharmacological and metabolic drugs protecting brain against hypoxia were studied. In 24 hours after the influence the animals have undergone the neurobehavioral testing and then were sacrificed, a number of neurochemical parameters depicting energy metabolism and metabolic GABA-bypath in brain were studied (general number of parameters were 24). Using classical method of t-statistics only enhancement of labelled GBA catabolism and deterioration of general behavioral activity were verified, the modifying effect of the pharmacological and metabolic protection against hypoxia was not found. Using methods of multidimensional evaluation the protective and sanogenic character of the used method of therapy was verified. Thus, using discrimination analysis (Mahalanobis criterion) high similarity of intact and treated groups of animals was estimated. It was confirmed using methods of coupled and multiple correlation and method of route coefficients. The statistical connections between neurochemical and neurobehavioral parameters were found which can be useful for understanding of the mechanisms of the early postradiation syndrome development.

AB - Three groups of rats (intact, irradiated with 30 Gy of γ-rays and threated after irradiation with the use of pharmacological and metabolic drugs protecting brain against hypoxia were studied. In 24 hours after the influence the animals have undergone the neurobehavioral testing and then were sacrificed, a number of neurochemical parameters depicting energy metabolism and metabolic GABA-bypath in brain were studied (general number of parameters were 24). Using classical method of t-statistics only enhancement of labelled GBA catabolism and deterioration of general behavioral activity were verified, the modifying effect of the pharmacological and metabolic protection against hypoxia was not found. Using methods of multidimensional evaluation the protective and sanogenic character of the used method of therapy was verified. Thus, using discrimination analysis (Mahalanobis criterion) high similarity of intact and treated groups of animals was estimated. It was confirmed using methods of coupled and multiple correlation and method of route coefficients. The statistical connections between neurochemical and neurobehavioral parameters were found which can be useful for understanding of the mechanisms of the early postradiation syndrome development.

UR - http://www.scopus.com/inward/record.url?scp=0028386430&partnerID=8YFLogxK

M3 - статья

AN - SCOPUS:0028386430

VL - 34

SP - 292

EP - 299

JO - РАДИАЦИОННАЯ БИОЛОГИЯ. РАДИОЭКОЛОГИЯ

JF - РАДИАЦИОННАЯ БИОЛОГИЯ. РАДИОЭКОЛОГИЯ

SN - 0869-8031

IS - 2

ER -

ID: 42769014