Potential difference across the frog skin is increased 1-2 min after addition of 0.063-1.0 mg/ml ethacrynic acid or 0.2-1.0 mg/ml mercusal to outside Ringer solution. Within this time the short-circuit current remains unchanged or increased. Potential difference and short-circuit current are diminished after the addition of ethacrynic acid or mercusal to inside solution. This effect is similar to that of ouabain. These findings suggest that ethacrynic acid and mercusal inhibit chloride channel in the apical cell membrane, and inhibit sodium transport in the basolateral membrane.
|Number of pages||6|
|Publication status||Published - 1 Jul 1981|
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