Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Nataliia Sergeevna Novikova, Anastasiia Sergeevna Diatlova, Kristina Zurabovna Derevtsova, Elena Andreevna Korneva, Tamara Viktorovna Fedotkina, Yuri Ostrinki, Lital Abraham, Shir Quinn, Yahel Segal, Leonid Churilov, Miri Blank, Yehuda Shoenfeld, Rina Aharoni, Howard Amital

Research output

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

Original languageEnglish
Pages (from-to)577070
JournalJournal of Neuroimmunology
Volume337
Early online date24 Oct 2019
DOIs
Publication statusPublished - Dec 2019

Fingerprint

Tuftsin
Phosphorylcholine
Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Central Nervous System
Autoimmune Diseases of the Nervous System
Nerve Tissue
Helminths
Demyelinating Diseases
Disease Progression
Chronic Disease
Inflammation
Morbidity
Mortality

Cite this

Novikova, Nataliia Sergeevna ; Diatlova, Anastasiia Sergeevna ; Derevtsova, Kristina Zurabovna ; Korneva, Elena Andreevna ; Fedotkina, Tamara Viktorovna ; Ostrinki, Yuri ; Abraham, Lital ; Quinn, Shir ; Segal, Yahel ; Churilov, Leonid ; Blank, Miri ; Shoenfeld, Yehuda ; Aharoni, Rina ; Amital, Howard. / Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. In: Journal of Neuroimmunology. 2019 ; Vol. 337. pp. 577070.
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abstract = "Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.",
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Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. / Novikova, Nataliia Sergeevna; Diatlova, Anastasiia Sergeevna; Derevtsova, Kristina Zurabovna; Korneva, Elena Andreevna; Fedotkina, Tamara Viktorovna; Ostrinki, Yuri; Abraham, Lital; Quinn, Shir; Segal, Yahel; Churilov, Leonid; Blank, Miri; Shoenfeld, Yehuda; Aharoni, Rina; Amital, Howard.

In: Journal of Neuroimmunology, Vol. 337, 12.2019, p. 577070.

Research output

TY - JOUR

T1 - Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

AU - Novikova, Nataliia Sergeevna

AU - Diatlova, Anastasiia Sergeevna

AU - Derevtsova, Kristina Zurabovna

AU - Korneva, Elena Andreevna

AU - Fedotkina, Tamara Viktorovna

AU - Ostrinki, Yuri

AU - Abraham, Lital

AU - Quinn, Shir

AU - Segal, Yahel

AU - Churilov, Leonid

AU - Blank, Miri

AU - Shoenfeld, Yehuda

AU - Aharoni, Rina

AU - Amital, Howard

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2019/12

Y1 - 2019/12

N2 - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

AB - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

KW - Tuftsin-phosphorylcholine

KW - Experimental autoimmune encephalomyelitis

KW - AutoimmunityMultiple sclerosis

U2 - 10.1016/j.jneuroim.2019.577070

DO - 10.1016/j.jneuroim.2019.577070

M3 - Article

C2 - 31683117

VL - 337

SP - 577070

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -