Three-component working electrode Ag particles/TiO2 layer/Ti surface: template electrochemical synthesis and potential use as electrochemical sensor for glutathione detection

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Abstract

In the present work the possibility is considered of a chemical sensor synthesis for quantitative glutathione (GSH) determination. Sensor is based on a composite working electrode containing an array of micron-sized Ag particles immobilized on a conductive substrate (Ti) coated by dielectric TiO2 film. To determine GSH in biological fluids, particularly, in saliva, electrochemical silver-based sensors can be used, since such sensors contain –SH group. With the use of cyclic voltammetry (CV) with a composite working electrode containing an Ag microparticles array, the threshold of quantitative GSH determination is reduced to nM level. Since other modern analogues are inferior at least one order of magnitude in the limit of quantitative GSH detection, we assume that the proposed sensor may be of great interest for clinical diagnosis.
Original languageEnglish
Article number035401
JournalMaterials Research Express
Volume7
Issue number3
StateAccepted/In press - 2019

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