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The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof. / Komarova, Kristina Yu.; Lukin, Alexey Yu.; Vinogradova, Lyubov V.; Zhuravlev, Maxim E.; Dogonadze, Marine Z.; Vinogradova, Tatiana I.; Gureev, Maxim A.; Chudinov, Mikhail V.; Dar’in, Dmitry V.

In: Chemistry of Heterocyclic Compounds, Vol. 60, No. 5-6, 21.08.2024, p. 245-250.

Research output: Contribution to journal › Article › peer-review

Harvard

Komarova, KY, Lukin, AY, Vinogradova, LV, Zhuravlev, ME, Dogonadze, MZ, Vinogradova, TI, Gureev, MA, Chudinov, MV & Dar’in, DV 2024, 'The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof', Chemistry of Heterocyclic Compounds, vol. 60, no. 5-6, pp. 245-250. https://doi.org/10.1007/s10593-024-03328-w

APA

Komarova, K. Y., Lukin, A. Y., Vinogradova, L. V., Zhuravlev, M. E., Dogonadze, M. Z., Vinogradova, T. I., Gureev, M. A., Chudinov, M. V., & Dar’in, D. V. (2024). The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof. Chemistry of Heterocyclic Compounds, 60(5-6), 245-250. https://doi.org/10.1007/s10593-024-03328-w

Vancouver

Komarova KY, Lukin AY, Vinogradova LV, Zhuravlev ME, Dogonadze MZ, Vinogradova TI et al. The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof. Chemistry of Heterocyclic Compounds. 2024 Aug 21;60(5-6):245-250. https://doi.org/10.1007/s10593-024-03328-w

Author

Komarova, Kristina Yu. ; Lukin, Alexey Yu. ; Vinogradova, Lyubov V. ; Zhuravlev, Maxim E. ; Dogonadze, Marine Z. ; Vinogradova, Tatiana I. ; Gureev, Maxim A. ; Chudinov, Mikhail V. ; Dar’in, Dmitry V. / The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof. In: Chemistry of Heterocyclic Compounds. 2024 ; Vol. 60, No. 5-6. pp. 245-250.

BibTeX

@article{f551f3126a2343eab2e03b3160585b45,
title = "The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof",
abstract = "(Figure presented.) The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M. tu- berculosis containing the 1-oxa-9-azaspiro[5.5]undecane scaffold. Optimization of the initial structure was performed with consideration of the results of molecular docking. The resulting compounds, characterized by the chemical diversity of the peripheral fragment, showed high activity against the antibiotic-sensitive strain H37Rv and some multiresistant strains of M. tuberculosis, exceeding the activity of the comparator drug.",
keywords = "1-oxa-9-azaspiro[5.5]undecane, MmpL3 protein, Prins cyclization, antituberculosis activity, spirocyclic compounds",
author = "Komarova, {Kristina Yu.} and Lukin, {Alexey Yu.} and Vinogradova, {Lyubov V.} and Zhuravlev, {Maxim E.} and Dogonadze, {Marine Z.} and Vinogradova, {Tatiana I.} and Gureev, {Maxim A.} and Chudinov, {Mikhail V.} and Dar{\textquoteright}in, {Dmitry V.}",
year = "2024",
month = aug,
day = "21",
doi = "10.1007/s10593-024-03328-w",
language = "English",
volume = "60",
pages = "245--250",
journal = "Chemistry of Heterocyclic Compounds",
issn = "0009-3122",
publisher = "Springer Nature",
number = "5-6",

}

RIS

TY - JOUR

T1 - The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof

AU - Komarova, Kristina Yu.

AU - Lukin, Alexey Yu.

AU - Vinogradova, Lyubov V.

AU - Zhuravlev, Maxim E.

AU - Dogonadze, Marine Z.

AU - Vinogradova, Tatiana I.

AU - Gureev, Maxim A.

AU - Chudinov, Mikhail V.

AU - Dar’in, Dmitry V.

PY - 2024/8/21

Y1 - 2024/8/21

N2 - (Figure presented.) The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M. tu- berculosis containing the 1-oxa-9-azaspiro[5.5]undecane scaffold. Optimization of the initial structure was performed with consideration of the results of molecular docking. The resulting compounds, characterized by the chemical diversity of the peripheral fragment, showed high activity against the antibiotic-sensitive strain H37Rv and some multiresistant strains of M. tuberculosis, exceeding the activity of the comparator drug.

AB - (Figure presented.) The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M. tu- berculosis containing the 1-oxa-9-azaspiro[5.5]undecane scaffold. Optimization of the initial structure was performed with consideration of the results of molecular docking. The resulting compounds, characterized by the chemical diversity of the peripheral fragment, showed high activity against the antibiotic-sensitive strain H37Rv and some multiresistant strains of M. tuberculosis, exceeding the activity of the comparator drug.

KW - 1-oxa-9-azaspiro[5.5]undecane

KW - MmpL3 protein

KW - Prins cyclization

KW - antituberculosis activity

KW - spirocyclic compounds

UR - https://www.mendeley.com/catalogue/bee764e3-be52-3560-b25b-5b8f7b832679/

U2 - 10.1007/s10593-024-03328-w

DO - 10.1007/s10593-024-03328-w

M3 - Article

VL - 60

SP - 245

EP - 250

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

SN - 0009-3122

IS - 5-6

ER -

ID: 124082336