The spatial-frequency characteristics of the visual system in schizophrenia

I.I. Shoshina, Y.E. Shelepin, E.A. Vershinina, K.O. Novikova

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© 2015, Pleiades Publishing, Inc. The spatial-frequency characteristics of the visual system were studied in mentally healthy persons and in patients with schizophrenia using a test of contrast sensivity in a comparison of the contrast of two gratings with sinusoidal distribution of brightness and with the low, medium, or high spatial frequencies, which are perceived by neurons of the magnocellular and parvocellular channels with different sensitivities. In the first-episode schizophrenic patients who had received no antipsychotic drugs for a long time, an enhancement of contrast sensitivity as compared to mentally healthy subjects was observed when the patients were presented Gabor gratings with low spatial frequencies to which the magnocellular channel neurons are most sensitive. On the contrary, in the case of the contrast comparison of the gratings with the medium and high spatial frequencies, the contrast sensitivity was reduced in the first-episode schizophrenic patients irrespective of whether they had
Original languageEnglish
Pages (from-to)251-260
JournalHuman Physiology
Issue number3
StatePublished - 2015

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