Research output: Contribution to journal › Article › peer-review
The sigma-1 receptor ligands chlorpromazine and trifluoperazine inhibit Na+ transport in frog skin epithelium. / Melnitskaya, A.V.; Krutetskaya, Z.I.; Antonov, V.G.; Krutetskaya, N.I.
In: Biophysics (Russian Federation), Vol. 65, No. 5, 09.2020, p. 784-787.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The sigma-1 receptor ligands chlorpromazine and trifluoperazine inhibit Na+ transport in frog skin epithelium
AU - Melnitskaya, A.V.
AU - Krutetskaya, Z.I.
AU - Antonov, V.G.
AU - Krutetskaya, N.I.
N1 - Publisher Copyright: © 2020, Pleiades Publishing, Inc.
PY - 2020/9
Y1 - 2020/9
N2 - Using the voltage-clamp technique, it has been shown for the first time that the neuroleptic drugs chlorpromazine and trifluoperazine, which act as sigma-1 receptor antagonists, attenuate Na + transport in the frog skin epithelium. The results suggest that sigma-1 receptors may be involved in the regulation of transepithelial Na + transport in frog skin.
AB - Using the voltage-clamp technique, it has been shown for the first time that the neuroleptic drugs chlorpromazine and trifluoperazine, which act as sigma-1 receptor antagonists, attenuate Na + transport in the frog skin epithelium. The results suggest that sigma-1 receptors may be involved in the regulation of transepithelial Na + transport in frog skin.
KW - Keywords: sigma-1 receptors
KW - Na transport
KW - chlorpromazine
KW - trifluoperazine
KW - Na+ transport
UR - http://www.scopus.com/inward/record.url?scp=85097386469&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/a956a8ca-5770-3fd7-8190-eb24ed622d62/
U2 - 10.1134/S0006350920050115
DO - 10.1134/S0006350920050115
M3 - Article
VL - 65
SP - 784
EP - 787
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 5
ER -
ID: 71872808