The sbr Gene Product in Drosophila melanogaster and Its Orthologs in Yeast (Mex67p) and Human (TAP)

I. V. Tretyakova, G. T. Lyozin, E. G. Markova, M. B. Evgen'ev, L. A. Mamon

Research output

7 Citations (Scopus)

Abstract

A DNA sequence from the 9F region of Drosophila melanogaster polytene chromosomes was cloned. Sequencing the cloned region and its comparison with the known sequences of the D. melanogaster genome showed that the cloned DNA part contains gene sbr and adjacent sequences. The literature data on the structure and functions of genes TAP in humans and Mex67 in yeast are discussed. These genes are orthologous to the sbr gene of Drosophila and control mRNA export from the nucleus to the cytoplasm. The literature evidence is consistent with the recessive expression of mutation l(l)ts403 (sbr10) upon heat treatment that is manifested as impaired HSP synthesis at the posttranscriptional level. However, it fails to explain the semidominant effect of the mutation manifested in high frequency of meiotic sex-chromosome nondisjunction in heat-treated females. A comparison of amino-acid sequences corresponding to the products of the three orthologous genes, TAP, Mex67, and sbr, showed that the sbr gene product of Drosophila is more similar to the human TAP factor than to the Mex67 factor in yeast.

Original languageEnglish
Pages (from-to)593-602
Number of pages10
JournalRussian Journal of Genetics
Volume37
Issue number6
DOIs
Publication statusPublished - 1 Jun 2001

Fingerprint

Drosophila melanogaster
Yeasts
Genes
Drosophila
Hot Temperature
Polytene Chromosomes
Mutation
Sex Chromosomes
Amino Acid Sequence
Cytoplasm
Genome
Messenger RNA
DNA

Scopus subject areas

  • Genetics

Cite this

@article{47f8c7506c914ca3bb030814bd1b5c72,
title = "The sbr Gene Product in Drosophila melanogaster and Its Orthologs in Yeast (Mex67p) and Human (TAP)",
abstract = "A DNA sequence from the 9F region of Drosophila melanogaster polytene chromosomes was cloned. Sequencing the cloned region and its comparison with the known sequences of the D. melanogaster genome showed that the cloned DNA part contains gene sbr and adjacent sequences. The literature data on the structure and functions of genes TAP in humans and Mex67 in yeast are discussed. These genes are orthologous to the sbr gene of Drosophila and control mRNA export from the nucleus to the cytoplasm. The literature evidence is consistent with the recessive expression of mutation l(l)ts403 (sbr10) upon heat treatment that is manifested as impaired HSP synthesis at the posttranscriptional level. However, it fails to explain the semidominant effect of the mutation manifested in high frequency of meiotic sex-chromosome nondisjunction in heat-treated females. A comparison of amino-acid sequences corresponding to the products of the three orthologous genes, TAP, Mex67, and sbr, showed that the sbr gene product of Drosophila is more similar to the human TAP factor than to the Mex67 factor in yeast.",
author = "Tretyakova, {I. V.} and Lyozin, {G. T.} and Markova, {E. G.} and Evgen'ev, {M. B.} and Mamon, {L. A.}",
year = "2001",
month = "6",
day = "1",
doi = "10.1023/A:1016623304741",
language = "English",
volume = "37",
pages = "593--602",
journal = "Russian Journal of Genetics",
issn = "1022-7954",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "6",

}

The sbr Gene Product in Drosophila melanogaster and Its Orthologs in Yeast (Mex67p) and Human (TAP). / Tretyakova, I. V.; Lyozin, G. T.; Markova, E. G.; Evgen'ev, M. B.; Mamon, L. A.

In: Russian Journal of Genetics, Vol. 37, No. 6, 01.06.2001, p. 593-602.

Research output

TY - JOUR

T1 - The sbr Gene Product in Drosophila melanogaster and Its Orthologs in Yeast (Mex67p) and Human (TAP)

AU - Tretyakova, I. V.

AU - Lyozin, G. T.

AU - Markova, E. G.

AU - Evgen'ev, M. B.

AU - Mamon, L. A.

PY - 2001/6/1

Y1 - 2001/6/1

N2 - A DNA sequence from the 9F region of Drosophila melanogaster polytene chromosomes was cloned. Sequencing the cloned region and its comparison with the known sequences of the D. melanogaster genome showed that the cloned DNA part contains gene sbr and adjacent sequences. The literature data on the structure and functions of genes TAP in humans and Mex67 in yeast are discussed. These genes are orthologous to the sbr gene of Drosophila and control mRNA export from the nucleus to the cytoplasm. The literature evidence is consistent with the recessive expression of mutation l(l)ts403 (sbr10) upon heat treatment that is manifested as impaired HSP synthesis at the posttranscriptional level. However, it fails to explain the semidominant effect of the mutation manifested in high frequency of meiotic sex-chromosome nondisjunction in heat-treated females. A comparison of amino-acid sequences corresponding to the products of the three orthologous genes, TAP, Mex67, and sbr, showed that the sbr gene product of Drosophila is more similar to the human TAP factor than to the Mex67 factor in yeast.

AB - A DNA sequence from the 9F region of Drosophila melanogaster polytene chromosomes was cloned. Sequencing the cloned region and its comparison with the known sequences of the D. melanogaster genome showed that the cloned DNA part contains gene sbr and adjacent sequences. The literature data on the structure and functions of genes TAP in humans and Mex67 in yeast are discussed. These genes are orthologous to the sbr gene of Drosophila and control mRNA export from the nucleus to the cytoplasm. The literature evidence is consistent with the recessive expression of mutation l(l)ts403 (sbr10) upon heat treatment that is manifested as impaired HSP synthesis at the posttranscriptional level. However, it fails to explain the semidominant effect of the mutation manifested in high frequency of meiotic sex-chromosome nondisjunction in heat-treated females. A comparison of amino-acid sequences corresponding to the products of the three orthologous genes, TAP, Mex67, and sbr, showed that the sbr gene product of Drosophila is more similar to the human TAP factor than to the Mex67 factor in yeast.

UR - http://www.scopus.com/inward/record.url?scp=0345817188&partnerID=8YFLogxK

U2 - 10.1023/A:1016623304741

DO - 10.1023/A:1016623304741

M3 - Review article

AN - SCOPUS:0345817188

VL - 37

SP - 593

EP - 602

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 6

ER -