The known function of the evolutionary conservative NXF1 (Nuclear eXport Factor) is the nuclear-cytoplasmic transport of the most mRNAs. On our data Dm NXF1 is involved in control of cell division. By immunostaining of early embryos with antibodies to C-terminal part of Dm NXF1 we have shown that the intensity of the staining depends on the cell cycle stage. The cytoplasmic Dm NXF1 is abundant on prometaphase and it almost disappears on anaphase. It is possible that Dm NXF1 can be involved in RNP-complexes including mRNAs which translation is regulated during cell cycle. Such complexes dissociate to resolve the translation of according mRNAs.
|Title of host publication||Encyclopedia of Cell Biology Research|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||7|
|Publication status||Published - 1 Mar 2012|
Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)