The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes

Ludmila Mamon, Anna Yakimova, Daria Kopytova, Elena Golubkova

Research output: Contribution to journalArticlepeer-review

Abstract

Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic localization of the SBR protein indicates that the nuclear export function is not the only function of this gene in Drosophila. RNA-binding protein SBR enriches the nucleus and cytoplasm of specific neurons and glial cells. In sbr12 mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. RNA-binding protein SBR participates in processes allowing axons to reach and identify their targets.

Original languageEnglish
Article number1144
JournalCells
Volume10
Issue number5
DOIs
StatePublished - 10 May 2021

Scopus subject areas

  • Medicine(all)

Keywords

  • Drosophila
  • neurogenesis
  • NXF
  • optic lobe
  • RNA-binding protein

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