The present-day perception of the problem of immune restoration of upon art

N. A. Belyakov, T. N. Trofimova, E. V. Boeva, M. D. Semenova

Research output

1 Citation (Scopus)

Abstract

Antiretroviral therapy (ART), which is intended to inhibit HIV replication, promotes partial restoration or activation of immunity. In many patients who have severe immunosuppression, ART may increase the risk of development of immune restoration syndrome (IRS), which is associated with the manifestations of opportunistic and secondary diseases that lead to worsening of the general health of patients and to their death. The present paper addresses IRS-related terminology, the risk factors of IRS development, and IRS pathogenesis, epidemiology, and clinical and laboratory manifestations. Special attention is paid to secondary and opportunistic infections associated with IRS and to the possibilities of pharmacotherapy for IRS and its complications. Characteristic radiological manifestations of brain lesions upon IRS are described as they as associated with different pathogenic factors upon initially poor immunity. It is hard to assess IRS incidence in Russia: IRS is diagnosed seldom because of the ambiguity of its clinical picture. A combination of the main clinical and laboratory manifestations of the syndrome is suggested to help in IRS diagnosis. IRS prevention is based on reasonable regiments of ART following preventing therapy for possible manifested infections and also on early ART onset upon steady CD4 cell counts and low HIV RNA blood levels.

Original languageEnglish
Pages (from-to)14-27
Number of pages14
JournalHIV Infection and Immunosuppressive Disorders
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Art
Immunity
HIV
Russia
Opportunistic Infections
Therapeutics
CD4 Lymphocyte Count
Secondary Prevention
Coinfection
Terminology
Immunosuppression
Epidemiology

Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

@article{20ee64425c9f4523a89dd92e74dd6b69,
title = "The present-day perception of the problem of immune restoration of upon art",
abstract = "Antiretroviral therapy (ART), which is intended to inhibit HIV replication, promotes partial restoration or activation of immunity. In many patients who have severe immunosuppression, ART may increase the risk of development of immune restoration syndrome (IRS), which is associated with the manifestations of opportunistic and secondary diseases that lead to worsening of the general health of patients and to their death. The present paper addresses IRS-related terminology, the risk factors of IRS development, and IRS pathogenesis, epidemiology, and clinical and laboratory manifestations. Special attention is paid to secondary and opportunistic infections associated with IRS and to the possibilities of pharmacotherapy for IRS and its complications. Characteristic radiological manifestations of brain lesions upon IRS are described as they as associated with different pathogenic factors upon initially poor immunity. It is hard to assess IRS incidence in Russia: IRS is diagnosed seldom because of the ambiguity of its clinical picture. A combination of the main clinical and laboratory manifestations of the syndrome is suggested to help in IRS diagnosis. IRS prevention is based on reasonable regiments of ART following preventing therapy for possible manifested infections and also on early ART onset upon steady CD4 cell counts and low HIV RNA blood levels.",
keywords = "ART, HIV, Immune restoration syndrome, Immunity, Opportunistic diseases",
author = "Belyakov, {N. A.} and Trofimova, {T. N.} and Boeva, {E. V.} and Semenova, {M. D.}",
year = "2018",
month = "1",
day = "1",
doi = "10.22328/2077-9828-2018-10-2-14-27",
language = "English",
volume = "10",
pages = "14--27",
journal = "ВИЧ-инфекция и иммуносупрессии",
issn = "2077-9828",
publisher = "БАЛТИЙСКИЙ МЕДИЦИНСКИЙ ОБРАЗОВАТЕЛЬНЫЙ ЦЕНТР",
number = "2",

}

The present-day perception of the problem of immune restoration of upon art. / Belyakov, N. A.; Trofimova, T. N.; Boeva, E. V.; Semenova, M. D.

In: HIV Infection and Immunosuppressive Disorders, Vol. 10, No. 2, 01.01.2018, p. 14-27.

Research output

TY - JOUR

T1 - The present-day perception of the problem of immune restoration of upon art

AU - Belyakov, N. A.

AU - Trofimova, T. N.

AU - Boeva, E. V.

AU - Semenova, M. D.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Antiretroviral therapy (ART), which is intended to inhibit HIV replication, promotes partial restoration or activation of immunity. In many patients who have severe immunosuppression, ART may increase the risk of development of immune restoration syndrome (IRS), which is associated with the manifestations of opportunistic and secondary diseases that lead to worsening of the general health of patients and to their death. The present paper addresses IRS-related terminology, the risk factors of IRS development, and IRS pathogenesis, epidemiology, and clinical and laboratory manifestations. Special attention is paid to secondary and opportunistic infections associated with IRS and to the possibilities of pharmacotherapy for IRS and its complications. Characteristic radiological manifestations of brain lesions upon IRS are described as they as associated with different pathogenic factors upon initially poor immunity. It is hard to assess IRS incidence in Russia: IRS is diagnosed seldom because of the ambiguity of its clinical picture. A combination of the main clinical and laboratory manifestations of the syndrome is suggested to help in IRS diagnosis. IRS prevention is based on reasonable regiments of ART following preventing therapy for possible manifested infections and also on early ART onset upon steady CD4 cell counts and low HIV RNA blood levels.

AB - Antiretroviral therapy (ART), which is intended to inhibit HIV replication, promotes partial restoration or activation of immunity. In many patients who have severe immunosuppression, ART may increase the risk of development of immune restoration syndrome (IRS), which is associated with the manifestations of opportunistic and secondary diseases that lead to worsening of the general health of patients and to their death. The present paper addresses IRS-related terminology, the risk factors of IRS development, and IRS pathogenesis, epidemiology, and clinical and laboratory manifestations. Special attention is paid to secondary and opportunistic infections associated with IRS and to the possibilities of pharmacotherapy for IRS and its complications. Characteristic radiological manifestations of brain lesions upon IRS are described as they as associated with different pathogenic factors upon initially poor immunity. It is hard to assess IRS incidence in Russia: IRS is diagnosed seldom because of the ambiguity of its clinical picture. A combination of the main clinical and laboratory manifestations of the syndrome is suggested to help in IRS diagnosis. IRS prevention is based on reasonable regiments of ART following preventing therapy for possible manifested infections and also on early ART onset upon steady CD4 cell counts and low HIV RNA blood levels.

KW - ART

KW - HIV

KW - Immune restoration syndrome

KW - Immunity

KW - Opportunistic diseases

UR - http://www.scopus.com/inward/record.url?scp=85049589244&partnerID=8YFLogxK

U2 - 10.22328/2077-9828-2018-10-2-14-27

DO - 10.22328/2077-9828-2018-10-2-14-27

M3 - Article

AN - SCOPUS:85049589244

VL - 10

SP - 14

EP - 27

JO - ВИЧ-инфекция и иммуносупрессии

JF - ВИЧ-инфекция и иммуносупрессии

SN - 2077-9828

IS - 2

ER -