ВЛИЯНИЕ КРАТКОВРЕМЕННОГО И ДЛИТЕЛЬНОГО НЕКОНТРОЛИРУЕМОГО СТРЕССА НА ЖИВОТНЫХ ДОМИНАНТНОГО И СУБОРДИНАНТНОГО СОЦИАЛЬНОГО СТАТУСА С РАЗЛИЧНЫМ ТИПОМ СТРЕССОРНОЙ РЕАКЦИИ

В. В. Немец, В. И. Шмурак, В. Е. Соболев, В. В. Гарнюк, Е. Д. Рован, Е. П. Виноградова

Research outputpeer-review

Abstract

The aim of this study was to explore the effects of the short-term and subchronic uncontrolled stress on the behavior of animals with different of coping styles and social status. The short-term stress (forced 5-minute swimming) inhibits locomotion in subordinate rats with passive coping style, while dominants with active coping style exhibit only a slight stress reaction (grooming). Under subchronic uncontrolled stress (4-hour immobilization in confined cases for 5 days), active dominants, but not passive subordinate rats, develop the signs of a depression-like state, such as decreased body weight, increased anhedonia and anxiety, increased locomotory and research activity, and increased pain threshold, on the 5-th day of exposure, compared to the background. The subordinate rats with passive coping style show the stress reaction marked by the decreased locomotory and research activity and increased anxiety on the 5-th day of exposure. Thus, short-term and subchronic uncontrolled stress have different effects on animals with opposite social status and coping styles. These data can be useful for individual selection of appropriate antidepressants based on psychophysiological characteristics.
Translated title of the contributionThe Influence of Short-Term and Subchronic Uncontrollable Stress on Animalsof the Dominant and Subordinate Social Status with Different Coping Styles
Original languageRussian
Article number5
Pages (from-to)608-618
Number of pages11
JournalФИЗИОЛОГИЧЕСКИЙ ЖУРНАЛ ИМ. И.М. СЕЧЕНОВА
Volume105
Issue number5
DOIs
Publication statusPublished - 2019

Scopus subject areas

  • Neuroscience(all)

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