Abstract—One of the political trends of the latest decades in the Western Hemisphere is the emergence of sub-regional projects (UNASUR, ALBA, CELAC) offering multilateral interaction, aimed at meeting the needs of Latin American countries and based on values and ideals, contradicting the traditional Pan-American approach promoted by Washington. Appeared on the political scene recently new sub-regional groups have already demonstrated their efficiency in a number of regional cases. But does this fact mean that the OAS can be considered obsolete and untenable institution? Is there any possibility for constructive cooperation within the OAS framework, or sub-regional groups are to be recognized as sufficient? The author's position is that the OAS, still possessing the constructive potential, is a structure of a different order than other sub-regional groups.