The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital

Irina Lazareva, Vladimir Ageevets, Julia Sopova, Marina Lebedeva, Polina Starkova, Daria Likholetova, Maria Lebedeva, Vladimir Gostev, Vladimir Moiseenko, Vitaliy Egorenkov, Arina Navatskaya, Galina Mitroshina, Elena Myasnikova, Irina Tsvetkova, Yuri Lobzin, Sergey Sidorenko

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1 Scopus citations


Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.

Original languageEnglish
Article number104527
JournalInfection, Genetics and Evolution
StatePublished - Nov 2020

Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases


  • Antimicrobial resistance
  • Hypermucoviscous Klebsiella pneumoniae
  • New Delhi metallo-beta-lactamase 1
  • Virulence

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