THE EFFECTS OF EPIPHYSEAL PEPTIDES ON THE RELEASE OF IMMUNOGLOBULINS IN PEYER’S PATCHES IN RATS IN VITRO

O.A. Zimina, R.I. Kovalenko, A.D. Nozdrachev

Research output

Abstract

The effects of epiphyseal peptides (1 μg/ml) on the release of immunoglobulins into the incubation medium by isolated Peyer’s patches from non-immunized mice and mice immunized orally against ovalbumin were studied during 40-min incubations. The possibility that epiphyseal peptides act on adrenoreceptors of cells in secondary lymphoid organs in the small intestine was assessed using α- and β-adrenoreceptor blockers, i.e., phentolamine HCl (0.02 mg/ml) and anaprilin (0.06 mg/ml) respectively. Basal levels of secretory activity in control Peyer’s patches from immunized rats were 2.4 times (p <0.01) greater than for the lymphoid organs of non-immunized animals. The effects of epiphyseal peptides on the secretory activity of antibody-forming cells depended on the functional state of Peyer’s patches. Application of epiphyseal peptides led to a 35% increase (p <0.05) in the release of immunoglobulins from Peyer’s patches in non-immunized rats and a 25% decrease (p <0.05) in the release of antibody into the incub
Original languageEnglish
Pages (from-to)893-897
JournalNeuroscience and Behavioral Physiology
Issue number9
Publication statusPublished - 2003
Externally publishedYes

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