The effect of human leukocyte Antigens-DRB1 alleles on development of different tuberculosis forms in children

Anna Starshinova, Irina Dovgalyuk, Andrey Berkos, Yulia Ovchinnikova, Ludmila Bubnova, Piotr Yablonskiy

Research output

1 Citation (Scopus)

Abstract

Background: Nowadays, there is no doubt that the development of infectious process is determined not only by individual features of a human, but also by features of infection agent. It is commonly known that ability to form an adequate immune response is based on immunogenetic peculiarities of macroorganism. Methods: The immunogenetic study was performed in 228 children from 1 to 15 years old with different manifestations of tuberculosis (TB). Control group was consisted of 446 adult healthy donors-residents of the Northwestern region of Russia. Human leukocyte antigens (HLA)-DRB1∗ allelic genes were assessed in all individuals. Results: HLA-DRB1 alleles ∗01, ∗03, ∗11, ∗13, ∗07, and ∗15 were observed significantly rare in children with TB in comparison with healthy donors that may indicate their protective role in the development of the disease. It was also noticed that DRB1 ∗07 and ∗15 alleles were observed significantly rare in children with lung TB in comparison with other forms of disease that allows to assume a protective function of these alleles for lung TB with no influence on development of generalized TB. This assumption requires further researches. Conclusion: As a result of the study, statistically significant differences in the distribution of HLA-DRB1∗ alleles in children with TB in comparison with a control group for ∗01, ∗03, ∗11, ∗13, ∗07, ∗15, and ∗16 alleles were found. It may indicate their protective role in the development of TB. DRB1 ∗07 and ∗15 alleles were observed significantly rare in children with single TB than in children with generalized TB and healthy controls.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalInternational Journal of Mycobacteriology
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Fingerprint

HLA Antigens
Tuberculosis
Alleles
Immunogenetics
Tissue Donors
Lung
Control Groups
Russia
Infection
Research

Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Starshinova, Anna ; Dovgalyuk, Irina ; Berkos, Andrey ; Ovchinnikova, Yulia ; Bubnova, Ludmila ; Yablonskiy, Piotr. / The effect of human leukocyte Antigens-DRB1 alleles on development of different tuberculosis forms in children. In: International Journal of Mycobacteriology. 2018 ; Vol. 7, No. 2. pp. 117-121.
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The effect of human leukocyte Antigens-DRB1 alleles on development of different tuberculosis forms in children. / Starshinova, Anna; Dovgalyuk, Irina; Berkos, Andrey; Ovchinnikova, Yulia; Bubnova, Ludmila; Yablonskiy, Piotr.

In: International Journal of Mycobacteriology, Vol. 7, No. 2, 01.04.2018, p. 117-121.

Research output

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AU - Starshinova, Anna

AU - Dovgalyuk, Irina

AU - Berkos, Andrey

AU - Ovchinnikova, Yulia

AU - Bubnova, Ludmila

AU - Yablonskiy, Piotr

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N2 - Background: Nowadays, there is no doubt that the development of infectious process is determined not only by individual features of a human, but also by features of infection agent. It is commonly known that ability to form an adequate immune response is based on immunogenetic peculiarities of macroorganism. Methods: The immunogenetic study was performed in 228 children from 1 to 15 years old with different manifestations of tuberculosis (TB). Control group was consisted of 446 adult healthy donors-residents of the Northwestern region of Russia. Human leukocyte antigens (HLA)-DRB1∗ allelic genes were assessed in all individuals. Results: HLA-DRB1 alleles ∗01, ∗03, ∗11, ∗13, ∗07, and ∗15 were observed significantly rare in children with TB in comparison with healthy donors that may indicate their protective role in the development of the disease. It was also noticed that DRB1 ∗07 and ∗15 alleles were observed significantly rare in children with lung TB in comparison with other forms of disease that allows to assume a protective function of these alleles for lung TB with no influence on development of generalized TB. This assumption requires further researches. Conclusion: As a result of the study, statistically significant differences in the distribution of HLA-DRB1∗ alleles in children with TB in comparison with a control group for ∗01, ∗03, ∗11, ∗13, ∗07, ∗15, and ∗16 alleles were found. It may indicate their protective role in the development of TB. DRB1 ∗07 and ∗15 alleles were observed significantly rare in children with single TB than in children with generalized TB and healthy controls.

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