The 1,3-dipolar cycloaddition of adamantine-derived nitrones with maleimides

Alexander P. Molchanov, Valentina M. Lukina, Mariia M. Efremova, Anna A. Muryleva, Alexander V. Slita, Vladimir V. Zarubaev

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Adamantane-derived aldo- and ketonitrones react with maleimides giving corresponding isoxazolidines. In the case of aldonitrones reactions proceed giving the diastereomeric mixtures. The ratio of isomers is changing during the reaction process due to the reversibility of the cycloaddition reaction. The cytotoxic and virus-inhibiting activity against influenza virus was investigated for selected adducts.

Original languageEnglish
JournalSynthetic Communications
StateE-pub ahead of print - 18 Mar 2020

Scopus subject areas

  • Organic Chemistry


  • Adamantane
  • antiviral activity
  • cycloaddition
  • isoxazolidines
  • nitrones

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