Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number

Dmitry Gromov, Ingo Bulla, Ethan O. Romero-Severson

Research output

1 Citation (Scopus)

Abstract

An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R-0, is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples. (C) 2018 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)381-390
Number of pages10
JournalJournal of Theoretical Biology
Volume462
DOIs
Publication statusPublished - 7 Feb 2019

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abstract = "An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R-0, is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples. (C) 2018 Elsevier Ltd. All rights reserved.",
keywords = "Disease control, Basic reproduction number, Treatment, Compartmental epidemic model, Next generation matrix, MODEL, COINFECTION, DYNAMICS, HIV, R-0",
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AU - Romero-Severson, Ethan O.

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AB - An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R-0, is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples. (C) 2018 Elsevier Ltd. All rights reserved.

KW - Disease control

KW - Basic reproduction number

KW - Treatment

KW - Compartmental epidemic model

KW - Next generation matrix

KW - MODEL

KW - COINFECTION

KW - DYNAMICS

KW - HIV

KW - R-0

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EP - 390

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

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