Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Anastasia M Konstantinova, Liubov Kyrpychova, Jana Nemcova, Monica Sedivcova, Michele Bisceglia, Heinz Kutzner, Michal Zamecnik, Eva Sehnalkova, Michal Pavlovsky, Kamila Zateckova, Sergej Shvernik, Zuzana Spurkova, Michal Michal, Katrin Kerl, Dmitry V Kazakov

Research output

2 Citations (Scopus)

Abstract

Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 2019

Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

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