Synthesis of Substituted Indole-3-carboxylates by Iron(II)-Catalyzed Domino Isomerization of 3-Alkyl/aryl-4-aryl-5-methoxyisoxazoles

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14 Scopus citations

Abstract

The iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-arylisoxazoles provides a selective access to a wide range of structurally diverse highly substituted indole-3-carboxylates. The operational simplicity, high atom efficiency, and the use of stable starting materials and an inexpensive and low-toxicity catalyst are some of the attractive features of this tandem double ring-opening-ring-closure strategy.

Original languageEnglish
Pages (from-to)2784-2798
Number of pages15
JournalSynthesis (Germany)
Volume50
Issue number14
DOIs
StatePublished - 17 Jul 2018

Scopus subject areas

  • Catalysis
  • Organic Chemistry

Keywords

  • domino reactions
  • indoles
  • iron(II) chloride catalysis
  • isomerization
  • isoxazoles

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