Synthesis of Substituted Indole-3-carboxylates by Iron(II)-Catalyzed Domino Isomerization of 3-Alkyl/aryl-4-aryl-5-methoxyisoxazoles

Vladimir A. Bodunov, Ekaterina E. Galenko, Alexey V. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov

Research output

10 Citations (Scopus)


The iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-arylisoxazoles provides a selective access to a wide range of structurally diverse highly substituted indole-3-carboxylates. The operational simplicity, high atom efficiency, and the use of stable starting materials and an inexpensive and low-toxicity catalyst are some of the attractive features of this tandem double ring-opening-ring-closure strategy.

Original languageEnglish
Pages (from-to)2784-2798
Number of pages15
JournalSynthesis (Germany)
Issue number14
Publication statusPublished - 17 Jul 2018


Scopus subject areas

  • Catalysis
  • Organic Chemistry

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