Fifteen tris(2-hydroxypropyl)ammonium salts (TPA salts) were first synthesized by a direct reaction of proton transfer from carboxylic acids to tris(2-hydroxypropyl)amine. The composition and structure of synthesized TPA salts were confirmed by NMR (1H, 13C), FT-IR spectroscopy and elemental analysis. The crystal structure and conformation of the tris(2-hydroxypropyl)ammonium cation in salts of salicylic, nicotinic and malonic acids were studied by single-crystal X-ray diffraction. Thermal stability studies have shown that TPA salts are protic ionic liquids with melting temperatures below 100 °C or room-temperature ionic liquids or molten salts. Selected TPA salts were investigated for their antimicrobial activity against bacterial and fungus strains. In addition, it was shown for the first time that synthesized TPA salts can be used as potential buffer agents for 68Ga-radiolabeling of bifunctional chelating agents (BCA) and clinically relevant peptides (PSMA-11, PSMA-617, DOTA-NOC, DOTA-TATE).
Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Materials Chemistry