Synthesis and studies of structure and biological properties of D-homoanalogs of steroid estrogens

S.N. Morozkina, A.F. Fidarov, A.S. Mushtukov, S.I. Selivanov, G.L. Starova, A.G. Shawa

Research output

2 Citations (Scopus)

Abstract

In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. © 2013 Pleiades Publishing, Ltd.
Original languageEnglish
Pages (from-to)1869-1873
JournalRussian Journal of General Chemistry
Issue number10
DOIs
Publication statusPublished - 2013

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Estrogens
Steroids
Lead compounds
ursolic acid

Cite this

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abstract = "In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. {\circledC} 2013 Pleiades Publishing, Ltd.",
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Synthesis and studies of structure and biological properties of D-homoanalogs of steroid estrogens. / Morozkina, S.N.; Fidarov, A.F.; Mushtukov, A.S.; Selivanov, S.I.; Starova, G.L.; Shawa, A.G.

In: Russian Journal of General Chemistry, No. 10, 2013, p. 1869-1873.

Research output

TY - JOUR

T1 - Synthesis and studies of structure and biological properties of D-homoanalogs of steroid estrogens

AU - Morozkina, S.N.

AU - Fidarov, A.F.

AU - Mushtukov, A.S.

AU - Selivanov, S.I.

AU - Starova, G.L.

AU - Shawa, A.G.

PY - 2013

Y1 - 2013

N2 - In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. © 2013 Pleiades Publishing, Ltd.

AB - In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. © 2013 Pleiades Publishing, Ltd.

U2 - 10.1134/S1070363213100125

DO - 10.1134/S1070363213100125

M3 - Article

SP - 1869

EP - 1873

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 10

ER -