Spirocyclic motifs in natural products

Evgeny Chupakhin, Olga Babich, Alexander Prosekov, Lyudmila Asyakina, Mikhail Krasavin

    Research output

    7 Citations (Scopus)

    Abstract

    Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes.

    Original languageEnglish
    Article number4165
    Number of pages37
    JournalMolecules
    Volume24
    Issue number22
    DOIs
    Publication statusPublished - 17 Nov 2019

    Scopus subject areas

    • Drug Discovery
    • Analytical Chemistry
    • Chemistry (miscellaneous)
    • Molecular Medicine
    • Physical and Theoretical Chemistry
    • Pharmaceutical Science
    • Organic Chemistry

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