Spatiotemporal structure of cell fate decisions in murine neural crest

Ruslan Soldatov, Marketa Kaucka, Maria Eleni Kastriti, Julian Petersen, Tatiana Chontorotzea, Lukas Englmaier, Natalia Akkuratova, Yunshi Yang, Martin Häring, Viacheslav Dyachuk, Christoph Bock, Matthias Farlik, Michael L. Piacentino, Franck Boismoreau, Markus M. Hilscher, Chika Yokota, Xiaoyan Qian, Mats Nilsson, Marianne E. Bronner, Laura CrociWen Yu Hsiao, David A. Guertin, Jean Francois Brunet, Gian Giacomo Consalez, Patrik Ernfors, Kaj Fried, Peter V. Kharchenko, Igor Adameyko

Research output

43 Citations (Scopus)

Abstract

Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.

Original languageEnglish
Article numberaas9536
JournalScience
Volume364
Issue number6444
DOIs
Publication statusPublished - 7 Jun 2019

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    Soldatov, R., Kaucka, M., Kastriti, M. E., Petersen, J., Chontorotzea, T., Englmaier, L., Akkuratova, N., Yang, Y., Häring, M., Dyachuk, V., Bock, C., Farlik, M., Piacentino, M. L., Boismoreau, F., Hilscher, M. M., Yokota, C., Qian, X., Nilsson, M., Bronner, M. E., ... Adameyko, I. (2019). Spatiotemporal structure of cell fate decisions in murine neural crest. Science, 364(6444), [aas9536]. https://doi.org/10.1126/science.aas9536