Some Features of Surfactant Organization in DNA Solutions at Various NaCl Concentrations

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The photosensitive azobenzene-containing surfactant C-4-Azo-OC(6)TMAB is a promising agent for reversible DNA packaging in a solution. The simulation of the trans-isomer surfactant organization into associates in a solution with and without salt as well as its binding to DNA at different NaCl concentrations was carried out by molecular dynamics. Experimental data obtained by spectral and hydrodynamic methods were used to verify the results of simulation. It was shown that head-to-tail aggregates with close to antiparallel orientation of surfactant molecules were formed at certain NaCl and surfactant concentrations (below critical micelle concentration). Such aggregates have two positively charged ends, and therefore, they can be attracted to negatively charged DNA phosphates far located along the chain, as well as those that belong to different molecules. This contributes to the formation of intermolecular DNA-DNA contacts, and this way, the experimentally observed precipitation of DNA can be explained.

Original languageEnglish
Pages (from-to)18234-18243
Number of pages10
JournalACS Omega
Volume5
Issue number29
DOIs
StatePublished - 28 Jul 2020

Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Keywords

  • MOLECULAR-DYNAMICS SIMULATION
  • THERMODYNAMICS
  • CONDENSATION
  • MICELLES

Fingerprint

Dive into the research topics of 'Some Features of Surfactant Organization in DNA Solutions at Various NaCl Concentrations'. Together they form a unique fingerprint.

Cite this