Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases

M. A. Lytkina, E. V. Eliseenkov, V. P. Boyarskii, A. A. Petrov

Research output

2 Citations (Scopus)

Abstract

Free radical difluoromethylation of protonated heteroaromatic bases was accomplished using sodium difluoromethanesulfinate in combination with tert-butyl hydroperoxide in a two-phase system (methylene chloride–water) at room temperature. The difluoromethylation products of methyl pyridine-4-carboxylate, pyridine-4-carbonitrile, and 2-amino-1,3,4-thiadiazole were isolated on a preparative scale.

Original languageEnglish
Pages (from-to)539-546
Number of pages8
JournalRussian Journal of Organic Chemistry
Volume53
Issue number4
DOIs
Publication statusPublished - 2017
Externally publishedYes

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2-amino-1,3,4-thiadiazole
Sodium
tert-Butylhydroperoxide
Free Radicals
Temperature
pyridine

Scopus subject areas

  • Organic Chemistry

Cite this

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title = "Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases",
abstract = "Free radical difluoromethylation of protonated heteroaromatic bases was accomplished using sodium difluoromethanesulfinate in combination with tert-butyl hydroperoxide in a two-phase system (methylene chloride–water) at room temperature. The difluoromethylation products of methyl pyridine-4-carboxylate, pyridine-4-carbonitrile, and 2-amino-1,3,4-thiadiazole were isolated on a preparative scale.",
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Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases. / Lytkina, M. A.; Eliseenkov, E. V.; Boyarskii, V. P.; Petrov, A. A.

In: Russian Journal of Organic Chemistry, Vol. 53, No. 4, 2017, p. 539-546.

Research output

TY - JOUR

T1 - Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases

AU - Lytkina, M. A.

AU - Eliseenkov, E. V.

AU - Boyarskii, V. P.

AU - Petrov, A. A.

PY - 2017

Y1 - 2017

N2 - Free radical difluoromethylation of protonated heteroaromatic bases was accomplished using sodium difluoromethanesulfinate in combination with tert-butyl hydroperoxide in a two-phase system (methylene chloride–water) at room temperature. The difluoromethylation products of methyl pyridine-4-carboxylate, pyridine-4-carbonitrile, and 2-amino-1,3,4-thiadiazole were isolated on a preparative scale.

AB - Free radical difluoromethylation of protonated heteroaromatic bases was accomplished using sodium difluoromethanesulfinate in combination with tert-butyl hydroperoxide in a two-phase system (methylene chloride–water) at room temperature. The difluoromethylation products of methyl pyridine-4-carboxylate, pyridine-4-carbonitrile, and 2-amino-1,3,4-thiadiazole were isolated on a preparative scale.

UR - http://www.scopus.com/inward/record.url?scp=85020030242&partnerID=8YFLogxK

U2 - 10.1134/S1070428017040066

DO - 10.1134/S1070428017040066

M3 - Review article

AN - SCOPUS:85020030242

VL - 53

SP - 539

EP - 546

JO - Russian Journal of Organic Chemistry

JF - Russian Journal of Organic Chemistry

SN - 1070-4280

IS - 4

ER -