Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on Na+ transport in frog skin

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Abstract

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+
transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first
time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine
attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible
involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.
DOI: 10.1134/S1607672919010186
Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume484
Issue number1
DOIs
StatePublished - 1 May 2019

Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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