[Figure not available: see fulltext.] Addition of primary amines to 1-phenyl-5-trimethylsilylpenta-1,4-diyn-3-one with subsequent cyclization affords 5-phenyl-2-(trimethylsilylmethylidene)-1,2-dihydro-3H-pyrrol-3-ones. Both electron-rich and electron-deficient anilines and alkyl amines provide regio- and stereoselective formation of single product in high yields. The two-step transformation benefits from full atom economy, operational simplicity, and no need for additives and catalysts.
|Translated title of the contribution||Селективный синтез 2-метиленпиррол-3-онов из диинонов и аминов|
|Number of pages||4|
|Journal||Chemistry of Heterocyclic Compounds|
|Publication status||Published - 15 Jul 2019|
Scopus subject areas
- Organic Chemistry