Standard
Search for new drugs : Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles. / Anisimova, V. A.; Tolpygin, I. E.; Spasov, A. A.; Yakovlev, D. S.; Kolobrodova, N. A.; Gurova, N. A.; Salaznikova, O. A.; Naumenko, L. V.; Kosolapov, V. A.; El'tsova, L. V.; Mitina, T. M.; Voronkova, M. P.; Lenskaya, K. V.
In:
Pharmaceutical Chemistry Journal, Vol. 46, No. 6, 09.2012, p. 325-330.
Research output: Contribution to journal › Article › peer-review
Harvard
Anisimova, VA, Tolpygin, IE, Spasov, AA, Yakovlev, DS, Kolobrodova, NA, Gurova, NA, Salaznikova, OA, Naumenko, LV, Kosolapov, VA, El'tsova, LV, Mitina, TM, Voronkova, MP
& Lenskaya, KV 2012, '
Search for new drugs: Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles',
Pharmaceutical Chemistry Journal, vol. 46, no. 6, pp. 325-330.
https://doi.org/10.1007/s11094-012-0791-3,
https://doi.org/10.1007/s11094-012-0791-3APA
Anisimova, V. A., Tolpygin, I. E., Spasov, A. A., Yakovlev, D. S., Kolobrodova, N. A., Gurova, N. A., Salaznikova, O. A., Naumenko, L. V., Kosolapov, V. A., El'tsova, L. V., Mitina, T. M., Voronkova, M. P.
, & Lenskaya, K. V. (2012).
Search for new drugs: Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles.
Pharmaceutical Chemistry Journal,
46(6), 325-330.
https://doi.org/10.1007/s11094-012-0791-3,
https://doi.org/10.1007/s11094-012-0791-3Vancouver
Anisimova VA, Tolpygin IE, Spasov AA, Yakovlev DS, Kolobrodova NA, Gurova NA et al.
Search for new drugs: Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles.
Pharmaceutical Chemistry Journal. 2012 Sep;46(6):325-330.
https://doi.org/10.1007/s11094-012-0791-3,
https://doi.org/10.1007/s11094-012-0791-3Author
Anisimova, V. A. ; Tolpygin, I. E. ; Spasov, A. A. ; Yakovlev, D. S. ; Kolobrodova, N. A. ; Gurova, N. A. ; Salaznikova, O. A. ; Naumenko, L. V. ; Kosolapov, V. A. ; El'tsova, L. V. ; Mitina, T. M. ; Voronkova, M. P.
; Lenskaya, K. V. /
Search for new drugs : Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles. In:
Pharmaceutical Chemistry Journal. 2012 ; Vol. 46, No. 6. pp. 325-330.
BibTeX
@article{0e78a62d889546339648dc6c4ffa11a4,
title = "Search for new drugs: Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles",
abstract = "The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-α] benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT 2 antagonist activity; platelet antiaggregant properties; and moderate P2Y 1 -antagonist, antiarrhythmic, and hypoglycemic action.",
keywords = "2,3,4-10-tetrahydropyrimido[1,2-α]benzimidazole, 5-HT antagonist activity, Antiaggregant activity, Antiarrhythmic action, Hypoglycemic properties, P2Y -antagonist action, Synthesis",
author = "Anisimova, {V. A.} and Tolpygin, {I. E.} and Spasov, {A. A.} and Yakovlev, {D. S.} and Kolobrodova, {N. A.} and Gurova, {N. A.} and Salaznikova, {O. A.} and Naumenko, {L. V.} and Kosolapov, {V. A.} and El'tsova, {L. V.} and Mitina, {T. M.} and Voronkova, {M. P.} and Lenskaya, {K. V.}",
note = "Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",
year = "2012",
month = sep,
doi = "10.1007/s11094-012-0791-3",
language = "English",
volume = "46",
pages = "325--330",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer Nature",
number = "6",
}
RIS
TY - JOUR
T1 - Search for new drugs
T2 - Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido-[1,2-α]benzimidazoles
AU - Anisimova, V. A.
AU - Tolpygin, I. E.
AU - Spasov, A. A.
AU - Yakovlev, D. S.
AU - Kolobrodova, N. A.
AU - Gurova, N. A.
AU - Salaznikova, O. A.
AU - Naumenko, L. V.
AU - Kosolapov, V. A.
AU - El'tsova, L. V.
AU - Mitina, T. M.
AU - Voronkova, M. P.
AU - Lenskaya, K. V.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/9
Y1 - 2012/9
N2 - The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-α] benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT 2 antagonist activity; platelet antiaggregant properties; and moderate P2Y 1 -antagonist, antiarrhythmic, and hypoglycemic action.
AB - The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-α] benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT 2 antagonist activity; platelet antiaggregant properties; and moderate P2Y 1 -antagonist, antiarrhythmic, and hypoglycemic action.
KW - 2,3,4-10-tetrahydropyrimido[1,2-α]benzimidazole
KW - 5-HT antagonist activity
KW - Antiaggregant activity
KW - Antiarrhythmic action
KW - Hypoglycemic properties
KW - P2Y -antagonist action
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=84868329100&partnerID=8YFLogxK
U2 - 10.1007/s11094-012-0791-3
DO - 10.1007/s11094-012-0791-3
M3 - Article
AN - SCOPUS:84868329100
VL - 46
SP - 325
EP - 330
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 6
ER -
