This study aims to investigate the effect of eddies on synoptic variability of the sea-ice edge along the East Greenland Current (EGC) in the northwestern Greenland Sea. We use an eddy-resolving FESOM1.4 ocean model configuration with 1 km spatial resolution in the Fram Strait. The synoptic variations of the sea-ice area in the region proved to be a result of an interplay between the regional convergence of the sea-ice advected from the Arctic and a local sea-ice freezing or melting. Several case studies showed that eddies in the marginal ice zone (MIZ) can effectively decrease the ice area, resulting in a local retreat of the ice-edge by 3–8 km per day. However, these local retreats of the MIZ in the Greenland Sea are quickly restored by an enhanced convergence of the advected ice or, during the cold period, by atmospheric cooling, keeping the monthly mean MIZ position stable in time. The integral effect of eddies on the ice extent is to limit the ice spreading east from the EGC. The effect of the eddies resides on strong regional temperature gradients east of the MIZ formed by the convergence of the cold Polar Water with warm Recirculating Atlantic Water.