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Sarcoidosis as an Autoimmune Disease. / Starshinova, Anna A.; Malkova, Anna M. ; Basantsova, Natalia Y. ; Zinchenko, Yulia S. ; Kudryavtsev, Igor V. ; Ershov, Gennadiy A. ; Soprun, Lidia A. ; Mayevskaya, Vera A. ; Churilov, Leonid P. ; Yablonskiy, Piotr K. Yablonskiy.

In: Frontiers in Immunology, Vol. 10, 2933, 08.01.2020.

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@article{7798aa9e06b74ef7a95832ef26e65180,
title = "Sarcoidosis as an Autoimmune Disease",
abstract = "Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.",
keywords = "autoimmune diseases, connective tissue diseases, HLA genotype, sarcoidosis, triggering factors",
author = "Starshinova, {Anna A.} and Malkova, {Anna M.} and Basantsova, {Natalia Y.} and Zinchenko, {Yulia S.} and Kudryavtsev, {Igor V.} and Ershov, {Gennadiy A.} and Soprun, {Lidia A.} and Mayevskaya, {Vera A.} and Churilov, {Leonid P.} and Yablonskiy, {Piotr K. Yablonskiy}",
note = "Funding Information: This work was supported by grant from the Government of the Russian Federation (contract No. 14.W03.31.0009 dated February 13, 2017) on the allocation of grant for the state support of scientific researches conducted under the guidance of leading scientists.",
year = "2020",
month = jan,
day = "8",
doi = "10.3389/fimmu.2019.02933.",
language = "English",
volume = "10",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Sarcoidosis as an Autoimmune Disease

AU - Starshinova, Anna A.

AU - Malkova, Anna M.

AU - Basantsova, Natalia Y.

AU - Zinchenko, Yulia S.

AU - Kudryavtsev, Igor V.

AU - Ershov, Gennadiy A.

AU - Soprun, Lidia A.

AU - Mayevskaya, Vera A.

AU - Churilov, Leonid P.

AU - Yablonskiy, Piotr K. Yablonskiy

N1 - Funding Information: This work was supported by grant from the Government of the Russian Federation (contract No. 14.W03.31.0009 dated February 13, 2017) on the allocation of grant for the state support of scientific researches conducted under the guidance of leading scientists.

PY - 2020/1/8

Y1 - 2020/1/8

N2 - Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.

AB - Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.

KW - autoimmune diseases

KW - connective tissue diseases

KW - HLA genotype

KW - sarcoidosis

KW - triggering factors

UR - http://www.scopus.com/inward/record.url?scp=85078497204&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2019.02933.

DO - 10.3389/fimmu.2019.02933.

M3 - Article

C2 - 31969879

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2933

ER -

ID: 50333475