Research output: Contribution to journal › Article › peer-review
Sarcoidosis as an Autoimmune Disease. / Starshinova, Anna A.; Malkova, Anna M. ; Basantsova, Natalia Y. ; Zinchenko, Yulia S. ; Kudryavtsev, Igor V. ; Ershov, Gennadiy A. ; Soprun, Lidia A. ; Mayevskaya, Vera A. ; Churilov, Leonid P. ; Yablonskiy, Piotr K. Yablonskiy.
In: Frontiers in Immunology, Vol. 10, 2933, 08.01.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Sarcoidosis as an Autoimmune Disease
AU - Starshinova, Anna A.
AU - Malkova, Anna M.
AU - Basantsova, Natalia Y.
AU - Zinchenko, Yulia S.
AU - Kudryavtsev, Igor V.
AU - Ershov, Gennadiy A.
AU - Soprun, Lidia A.
AU - Mayevskaya, Vera A.
AU - Churilov, Leonid P.
AU - Yablonskiy, Piotr K. Yablonskiy
N1 - Funding Information: This work was supported by grant from the Government of the Russian Federation (contract No. 14.W03.31.0009 dated February 13, 2017) on the allocation of grant for the state support of scientific researches conducted under the guidance of leading scientists.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.
AB - Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.
KW - autoimmune diseases
KW - connective tissue diseases
KW - HLA genotype
KW - sarcoidosis
KW - triggering factors
UR - http://www.scopus.com/inward/record.url?scp=85078497204&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.02933.
DO - 10.3389/fimmu.2019.02933.
M3 - Article
C2 - 31969879
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 2933
ER -
ID: 50333475