Saccharin guanidination: Via facile three-component "two saccharins-one dialkylcyanamide" integration

Alexey Yu Dubovtsev, Daniil M. Ivanov, Uladzislava Dabranskaya, Nadezhda A. Bokach, Vadim Yu Kukushkin

Research output

Abstract

Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R2 = Me2, Et2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4-2-SO3-H)NC+(NH2)NR2 (65-91%) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates.

Original languageEnglish
Pages (from-to)10685-10688
Number of pages4
JournalNew Journal of Chemistry
Volume43
Issue number27
DOIs
Publication statusPublished - 1 Jan 2019

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Saccharin
Derivatives
Substrates
Nitriles

Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

Cite this

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title = "Saccharin guanidination: Via facile three-component {"}two saccharins-one dialkylcyanamide{"} integration",
abstract = "Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R2 = Me2, Et2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4-2-SO3-H)NC+(NH2)NR2 (65-91{\%}) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates.",
author = "Dubovtsev, {Alexey Yu} and Ivanov, {Daniil M.} and Uladzislava Dabranskaya and Bokach, {Nadezhda A.} and Kukushkin, {Vadim Yu}",
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T1 - Saccharin guanidination

T2 - Via facile three-component "two saccharins-one dialkylcyanamide" integration

AU - Dubovtsev, Alexey Yu

AU - Ivanov, Daniil M.

AU - Dabranskaya, Uladzislava

AU - Bokach, Nadezhda A.

AU - Kukushkin, Vadim Yu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R2 = Me2, Et2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4-2-SO3-H)NC+(NH2)NR2 (65-91%) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates.

AB - Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R2 = Me2, Et2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4-2-SO3-H)NC+(NH2)NR2 (65-91%) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates.

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U2 - 10.1039/c9nj02656h

DO - 10.1039/c9nj02656h

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JO - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

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